| |  Online-Ressource |
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| Verfasst von: | Nassrallah, Wissam B. [VerfasserIn]  |
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| | Ramandi, Daniel [VerfasserIn] |
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| | Cheng, Judy [VerfasserIn] |
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| | Oh, Jean [VerfasserIn] |
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| | Mackay, James [VerfasserIn] |
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| | Sepers, Marja D. [VerfasserIn] |
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| | Lau, David [VerfasserIn] |
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| | Bading, Hilmar [VerfasserIn] |
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| | Raymond, Lynn A. [VerfasserIn] |
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| Titel: | Activin A targets extrasynaptic NMDA receptors to ameliorate neuronal and behavioral deficits in a mouse model of Huntington disease |
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| Verf.angabe: | Wissam B. Nassrallah, Daniel Ramandi, Judy Cheng, Jean Oh, James Mackay, Marja D. Sepers, David Lau, Hilmar Bading, Lynn A. Raymond |
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| E-Jahr: | 2023 |
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| Jahr: | 20 November 2023 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 14.05.2024 |
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| Titel Quelle: | Enthalten in: Neurobiology of disease |
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| Ort Quelle: | [Amsterdam] : Elsevier, 1994 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 189(2023), Artikel-ID 106360, Seite 1-10 |
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| ISSN Quelle: | 1095-953X |
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| Abstract: | Cortical-striatal synaptic dysfunction, including enhanced toxic signaling by extrasynaptic N-methyl-d-aspartate receptors (eNMDARs), precedes neurodegeneration in Huntington disease (HD). A previous study showed Activin A, whose transcription is upregulated by calcium influx via synaptic NMDARs, suppresses eNMDAR signaling. Therefore, we examined the role of Activin A in the YAC128 HD mouse model, comparing it to wild-type controls. We found decreased Activin A secretion in YAC128 cortical-striatal co-cultures, while Activin A overexpression in this model rescued altered eNMDAR expression. Striatal overexpression of Activin A in vivo improved motor learning on the rotarod task, and normalized striatal neuronal eNMDAR-mediated currents, membrane capacitance and spontaneous excitatory postsynaptic current frequency in the YAC128 mice. These results support the therapeutic potential of Activin A signaling and targeting eNMDARs to restore striatal neuronal health and ameliorate behavioral deficits in HD. |
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| DOI: | doi:10.1016/j.nbd.2023.106360 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.nbd.2023.106360 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0969996123003765 |
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| | DOI: https://doi.org/10.1016/j.nbd.2023.106360 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Glutamatergic neurotransmission |
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| | Patch clamp recording |
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| | Striatal medium-sized spiny neuron |
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| | Synapse |
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| K10plus-PPN: | 188846559X |
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| Verknüpfungen: | → Zeitschrift |
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Activin A targets extrasynaptic NMDA receptors to ameliorate neuronal and behavioral deficits in a mouse model of Huntington disease / Nassrallah, Wissam B. [VerfasserIn]; 20 November 2023 (Online-Ressource)
