Consistency of the “central vein sign” in chronic multiple sclerosis lesions

• Verfasst von: Reichl, Matthias [VerfasserIn]
• Verfasst von: Wittayer, Matthias Sebastian [VerfasserIn]
• Verfasst von: Weber, Claudia Ellen [VerfasserIn]
• Verfasst von: Platten, Michael [VerfasserIn]
• Verfasst von: Gass, Achim [VerfasserIn]
• Verfasst von: Eisele, Philipp [VerfasserIn]
• Titel: Consistency of the “central vein sign” in chronic multiple sclerosis lesions
• Verf.angabe: Matthias Reichl, Matthias Wittayer, Claudia E. Weber, Michael Platten, Achim Gass, Philipp Eisele
• E-Jahr: 2022
• Jahr: February 2022
• Umfang: 4 S.
• Illustrationen: Illustrationen
• Fussnoten: Online verfügbar: 15. Januar 2022, Artikelversion: 21. Januar 2022 ; Im Titel ist “central vein sign” in Anführungszeichen geschrieben ; Gesehen am 14.05.2024
• Titel Quelle: Enthalten in: Multiple Sclerosis and Related Disorders
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 2012
• Jahr Quelle: 2022
• Band/Heft Quelle: 58(2022) vom: Feb., Artikel-ID 103530, Seite 1-4
• ISSN Quelle: 2211-0356
• DOI: doi:10.1016/j.msard.2022.103530
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Central vein sign
• Sach-SW: Multiple sclerosis
• Sach-SW: SWI
• K10plus-PPN: 1888538708

Abstract

Background - In recent years, there has been an increasing interest in the central vein sign (CVS) as a new imaging marker and previous cross-sectional studies demonstrated that the CVS has the potential to discriminate multiple sclerosis (MS) lesions from non-MS lesions. The aim of this study was to investigate the consistency of the CVS in a longitudinal magnetic resonance imaging (MRI) data set. - Methods - 3T MRI datasets from seventy-one people with MS acquired at baseline and after 12 months-follow-up were analyzed. Chronic lesions were identified on fluid-attenuated inversion recovery (FLAIR) images. Co-registered susceptibility-weighted/FLAIR images were analyzed for the presence of a CVS at baseline and follow-up. - Results - A total of 183 chronic lesions were included in the final analysis. At baseline MRI, a CVS was detectable in 141/183 (77%) lesions. Overall, the CVS was consistent in 114/141 (81%) lesions (Cohen's kappa = 0.46, standard error = 0.07). - Conclusion - The CVS is a rather stable feature in chronic MS lesions and therefore represents a robust imaging marker that could increase the specificity of MRI in MS.