| |  Online-Ressource |
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| Verfasst von: | Bächle, Christina [VerfasserIn]  |
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| | Eckert, A. [VerfasserIn] |
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| | Kamrath, C. [VerfasserIn] |
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| | Neu, A. [VerfasserIn] |
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| | Manuwald, Ulf [VerfasserIn] |
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| | Thiele-Schmitz, S. [VerfasserIn] |
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| | Weidler, O. [VerfasserIn] |
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| | Knauer-Fischer, Sabine [VerfasserIn] |
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| | Rosenbauer, J. [VerfasserIn] |
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| | Holl, R. W. [VerfasserIn] |
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| Titel: | Incidence and presentation of new-onset type 1 diabetes in children and adolescents from Germany during the COVID-19 pandemic 2020 and 2021 |
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| Titelzusatz: | current data from the DPV Registry |
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| Verf.angabe: | C. Baechle, A. Eckert, C. Kamrath, A. Neu, U. Manuwald, S. Thiele-Schmitz, O. Weidler, S. Knauer-Fischer, J. Rosenbauer, R.W. Holl |
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| E-Jahr: | 2023 |
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| Jahr: | March 2023 |
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| Umfang: | 9 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 8. Februar 2023, Artikelversion: 19. Februar 2023 ; Gesehen am 21.05.2024 |
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| Titel Quelle: | Enthalten in: Diabetes research and clinical practice |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1985 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 197(2023), Artikel-ID 110559, Seite 1-9 |
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| ISSN Quelle: | 1872-8227 |
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| Abstract: | Aims - To determine whether the incidence of type 1 diabetes mellitus (T1D), autoantibody-negative diabetes, and diabetic ketoacidosis (DKA) at diabetes onset in 2020 and 2021 changed when compared to long-standing trends. - Methods - Our study is based on diabetes manifestation data of the 0.5-<18-year-old children/adolescents from the German multicenter Diabetes Prospective Follow-up Registry. Based on long-term pre-pandemic trends from 2011 to 2019, we estimated adjusted incidence rate ratios (IRR) for T1D and DKA, and prevalence rate ratios (PRR) regarding autoantibody status with 95 % confidence intervals (CI) for the years 2020 and 2021 (observed versus predicted rates), using multivariable negative binomial or beta-binomial regression, respectively. - Results - We analyzed data of 30,840 children and adolescents with new-onset T1D. The observed incidences were significantly higher than the predicted incidences (IRR2020 1.13 [1.08-1.19]; IRR2021 1.20 [1.15-1.26]). The prevalence of autoantibody-negative diabetes did not change (PRR2020 0.91 [0.75-1.10]; PRR2021 1.03 [0.86-1.24]). The incidence of DKA during the pandemic was higher than predicted (IRR2020 1.34 [1.23-1.46]; IRR2021 1.37 [1.26-1.49]). - Conclusions - An increase in the incidences of T1D and DKA, but not of autoantibody-negative diabetes was observed during both pandemic years. Further monitoring and efforts for DKA prevention at onset are necessary. |
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| DOI: | doi:10.1016/j.diabres.2023.110559 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.diabres.2023.110559 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0168822723000347 |
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| | DOI: https://doi.org/10.1016/j.diabres.2023.110559 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adolescents |
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| | Diabetic ketoacidosis |
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| | Germany |
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| | Incidence |
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| | Registry |
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| | Type 1 diabetes |
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| K10plus-PPN: | 1889356603 |
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| Verknüpfungen: | → Zeitschrift |
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Incidence and presentation of new-onset type 1 diabetes in children and adolescents from Germany during the COVID-19 pandemic 2020 and 2021 / Bächle, Christina [VerfasserIn]; March 2023 (Online-Ressource)
