| Online-Ressource |
Verfasst von: | Beyer, Anika [VerfasserIn]  |
| Schorgg, Paula [VerfasserIn]  |
| Karavasiloglou, Nena [VerfasserIn]  |
| Sarwar, Sneha [VerfasserIn]  |
| Rohrmann, Sabine [VerfasserIn]  |
| Bärnighausen, Till [VerfasserIn]  |
| Cassidy, Aedin [VerfasserIn]  |
| Connolly, Lisa [VerfasserIn]  |
| Kühn, Tilman [VerfasserIn]  |
Titel: | Urinary phthalate concentrations and mortality risk |
Titelzusatz: | a population-based study |
Verf.angabe: | Anika Beyer, Paula Schorgg, Nena Karavasiloglou, Sneha Sarwar, Sabine Rohrmann, Till Bärnighausen, Aedin Cassidy, Lisa Connolly, and Tilman Kühn |
Verlagsort: | [S.l.] |
Verlag: | SSRN |
E-Jahr: | 2022 |
Jahr: | [2022] |
Umfang: | 1 Online-Ressource (20 p) |
Gesamttitel/Reihe: | ER-22-1812 |
Abstract: | Phthalates are widely used as plasticizers. Laboratory-based mechanistic and epidemiological studies suggest that phthalates are detrimental to human health. Here, we present prospective analyses on phthalate exposure and all-cause, as well as cause-specific, mortality from the National Health and Nutrition Examination Survey (NHANES), a population-based cohort. Between 1999 and 2010, urinary concentrations of 15 phthalate metabolites were measured by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry in spot urine samples of 6,314 adults aged 40 to 85 years, of which 1,441 died over a median follow-up duration of 9.8 years. Multivariable Cox regression analyses adjusted for a wide range of lifestyle factors and comorbidities showed that higher concentrations of mono-benzyl phthalate (MBzP) were associated with increased mortality. The hazard ratios for participants in the highest quartile of MBzP concentrations were at 1.25 [95% confidence interval: 1.07, 1.46; p linear trend = 0.01] for all-cause mortality and 1.29 [0.92, 1.81; p linear trend = 0.01] for cancer mortality. In addition, higher concentrations of Mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP, 1.84 [1.17, 2.90]; p linear trend = 0.02) and Mono-isobutyl phthalate (MiBP, 1.73 [1.01, 2.96; p linear trend = 0.02]) were positively associated with cardiovascular mortality. These findings reinforce the need for a regulation of phthalate use |
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kostenfrei: Verlag: https://ssrn.com/abstract=4053287 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1810324262 |
Urinary phthalate concentrations and mortality risk / Beyer, Anika [VerfasserIn]; [2022] (Online-Ressource)