Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Beyer, Anika [VerfasserIn]   i
 Schorgg, Paula [VerfasserIn]   i
 Karavasiloglou, Nena [VerfasserIn]   i
 Sarwar, Sneha [VerfasserIn]   i
 Rohrmann, Sabine [VerfasserIn]   i
 Bärnighausen, Till [VerfasserIn]   i
 Cassidy, Aedin [VerfasserIn]   i
 Connolly, Lisa [VerfasserIn]   i
 Kühn, Tilman [VerfasserIn]   i
Titel:Urinary phthalate concentrations and mortality risk
Titelzusatz:a population-based study
Verf.angabe:Anika Beyer, Paula Schorgg, Nena Karavasiloglou, Sneha Sarwar, Sabine Rohrmann, Till Bärnighausen, Aedin Cassidy, Lisa Connolly, and Tilman Kühn
Verlagsort:[S.l.]
Verlag:SSRN
E-Jahr:2022
Jahr:[2022]
Umfang:1 Online-Ressource (20 p)
Gesamttitel/Reihe:ER-22-1812
Abstract:Phthalates are widely used as plasticizers. Laboratory-based mechanistic and epidemiological studies suggest that phthalates are detrimental to human health. Here, we present prospective analyses on phthalate exposure and all-cause, as well as cause-specific, mortality from the National Health and Nutrition Examination Survey (NHANES), a population-based cohort. Between 1999 and 2010, urinary concentrations of 15 phthalate metabolites were measured by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry in spot urine samples of 6,314 adults aged 40 to 85 years, of which 1,441 died over a median follow-up duration of 9.8 years. Multivariable Cox regression analyses adjusted for a wide range of lifestyle factors and comorbidities showed that higher concentrations of mono-benzyl phthalate (MBzP) were associated with increased mortality. The hazard ratios for participants in the highest quartile of MBzP concentrations were at 1.25 [95% confidence interval: 1.07, 1.46; p linear trend = 0.01] for all-cause mortality and 1.29 [0.92, 1.81; p linear trend = 0.01] for cancer mortality. In addition, higher concentrations of Mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP, 1.84 [1.17, 2.90]; p linear trend = 0.02) and Mono-isobutyl phthalate (MiBP, 1.73 [1.01, 2.96; p linear trend = 0.02]) were positively associated with cardiovascular mortality. These findings reinforce the need for a regulation of phthalate use
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Verlag: https://ssrn.com/abstract=4053287
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1810324262

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69217439   QR-Code
zum Seitenanfang