Urinary phthalate concentrations and mortality risk

• Verfasst von: Beyer, Anika [VerfasserIn]
• Verfasst von: Schorgg, Paula [VerfasserIn]
• Verfasst von: Karavasiloglou, Nena [VerfasserIn]
• Verfasst von: Sarwar, Sneha [VerfasserIn]
• Verfasst von: Rohrmann, Sabine [VerfasserIn]
• Verfasst von: Bärnighausen, Till [VerfasserIn]
• Verfasst von: Cassidy, Aedin [VerfasserIn]
• Verfasst von: Connolly, Lisa [VerfasserIn]
• Verfasst von: Kühn, Tilman [VerfasserIn]
• Titel: Urinary phthalate concentrations and mortality risk
• Titelzusatz: a population-based study
• Verf.angabe: Anika Beyer, Paula Schorgg, Nena Karavasiloglou, Sneha Sarwar, Sabine Rohrmann, Till Bärnighausen, Aedin Cassidy, Lisa Connolly, and Tilman Kühn
• Verlagsort: [S.l.]
• Verlag: SSRN
• E-Jahr: 2022
• Jahr: [2022]
• Umfang: 1 Online-Ressource (20 p)
• Gesamttitel/Reihe: ER-22-1812
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1810324262

Abstract

Phthalates are widely used as plasticizers. Laboratory-based mechanistic and epidemiological studies suggest that phthalates are detrimental to human health. Here, we present prospective analyses on phthalate exposure and all-cause, as well as cause-specific, mortality from the National Health and Nutrition Examination Survey (NHANES), a population-based cohort. Between 1999 and 2010, urinary concentrations of 15 phthalate metabolites were measured by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry in spot urine samples of 6,314 adults aged 40 to 85 years, of which 1,441 died over a median follow-up duration of 9.8 years. Multivariable Cox regression analyses adjusted for a wide range of lifestyle factors and comorbidities showed that higher concentrations of mono-benzyl phthalate (MBzP) were associated with increased mortality. The hazard ratios for participants in the highest quartile of MBzP concentrations were at 1.25 [95% confidence interval: 1.07, 1.46; p linear trend = 0.01] for all-cause mortality and 1.29 [0.92, 1.81; p linear trend = 0.01] for cancer mortality. In addition, higher concentrations of Mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP, 1.84 [1.17, 2.90]; p linear trend = 0.02) and Mono-isobutyl phthalate (MiBP, 1.73 [1.01, 2.96; p linear trend = 0.02]) were positively associated with cardiovascular mortality. These findings reinforce the need for a regulation of phthalate use