Assessing long-term, vestibulotoxic side effects after gentamicin therapy in neonatal sepsis or infection using video head impulse test

• Verfasst von: Zaubitzer, Lena [VerfasserIn]
• Verfasst von: Kotzur, Anja [VerfasserIn]
• Verfasst von: Hegemann, Stefan [VerfasserIn]
• Verfasst von: Rotter, Nicole [VerfasserIn]
• Verfasst von: Schell, Angela [VerfasserIn]
• Titel: Assessing long-term, vestibulotoxic side effects after gentamicin therapy in neonatal sepsis or infection using video head impulse test
• Verf.angabe: Lena Zaubitzer, Anja Kotzur, Stefan Hegemann, Nicole Rotter and Angela Schell
• E-Jahr: 2024
• Jahr: 26 February 2024
• Umfang: 7 S.
• Fussnoten: Gesehen am 28.05.2024
• Titel Quelle: Enthalten in: Frontiers in Pediatrics
• Ort Quelle: Lausanne : Frontiers Media, 2013
• Jahr Quelle: 2024
• Band/Heft Quelle: 12(2024) vom: Feb., Artikel-ID 1366074, Seite 1-17
• ISSN Quelle: 2296-2360
• DOI: doi:10.3389/fped.2024.1366074
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Children
• Sach-SW: gain
• Sach-SW: Gentamicin
• Sach-SW: Newborn
• Sach-SW: refixational saccades
• Sach-SW: Sepsis
• Sach-SW: Vestibulotoxicity
• Sach-SW: Video head impulse test
• K10plus-PPN: 1890131814
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Question: Does gentamicin therapy in children with neonatal sepsis or infection lead to persistent vestibulotoxicity? Findings: In a single-center, prospective cross-sectional study video head impulse test (VHIT) was performed to evaluate vestibular function in 23 children aged 3-7 years at least three years after intravenous gentamicin therapy for neonatal sepsis or infection.Although eleven children showed abnormal results in vestibular testing, they did not present with a clinically significant vestibular hypofunction or delayed motoric development.VHIT can serve as a sensitive investigation method for the screening of posttherapeutic vestibulotoxic side effects after gentamicin therapy in children.