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| Verfasst von: | Reschke, Robin Niklas [VerfasserIn]  |
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| | Deitert, Benjamin [VerfasserIn] |
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| | Enk, Alexander [VerfasserIn] |
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| | Hassel, Jessica C. [VerfasserIn] |
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| Titel: | The role of tissue-resident memory T cells as mediators for response and toxicity in immunotherapy-treated melanoma |
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| Titelzusatz: | two sides of the same coin? |
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| Verf.angabe: | Robin Reschke, Benjamin Deitert, Alex H. Enk and Jessica C. Hassel |
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| E-Jahr: | 2024 |
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| Jahr: | 18 March 2024 |
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| Umfang: | 7 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 28.05.2024 |
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| Titel Quelle: | Enthalten in: Frontiers in immunology |
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| Ort Quelle: | Lausanne : Frontiers Media, 2010 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 15(2024) vom: März, Artikel-ID 1385781, Seite 1-7 |
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| ISSN Quelle: | 1664-3224 |
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| Abstract: | <p>Tissue-resident memory T cells (T<sub>RM</sub> cells) have become an interesting subject of study for antitumor immunity in melanoma and other solid tumors. In the initial phases of antitumor immunity, they maintain an immune equilibrium and protect against challenges with tumor cells and the formation of primary melanomas. In metastatic settings, they are a prime target cell population for immune checkpoint inhibition (ICI) because they highly express inhibitory checkpoint molecules such as PD-1, CTLA-4, or LAG-3. Once melanoma patients are treated with ICI, T<sub>RM</sub> cells residing in the tumor are reactivated and expand. Tumor killing is achieved by secreting effector molecules such as IFN-γ. However, off-target effects are also observed. Immune-related adverse events, such as those affecting barrier organs like the skin, can be mediated by ICI-induced T<sub>RM</sub> cells. Therefore, a detailed understanding of this memory T-cell type is obligatory to better guide and improve immunotherapy regimens.</p> |
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| DOI: | doi:10.3389/fimmu.2024.1385781 |
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| URL: | kostenfrei: Volltext: https://doi.org/10.3389/fimmu.2024.1385781 |
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| | kostenfrei: Volltext: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1385781/full |
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| | DOI: https://doi.org/10.3389/fimmu.2024.1385781 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | biomarker |
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| | Immune check inhibitor (ICI) |
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| | Immune related adverse effects (irAEs) |
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| | Immunotherapy |
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| | irAE |
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| | Melanoma |
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| | tissue resident memory T cells (TRM) |
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| | TRM cells |
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| K10plus-PPN: | 1890141747 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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¬The¬ role of tissue-resident memory T cells as mediators for response and toxicity in immunotherapy-treated melanoma / Reschke, Robin Niklas [VerfasserIn]; 18 March 2024 (Online-Ressource)
