| |  Online-Ressource |
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| Verfasst von: | Rathay, Veronika [VerfasserIn]  |
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| | Fürle, Kristin [VerfasserIn] |
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| | Kiehl, Viktoria [VerfasserIn] |
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| | Ulmer, Anne [VerfasserIn] |
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| | Lanzer, Michael [VerfasserIn] |
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| | Thomson-Luque, Richard [VerfasserIn] |
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| Titel: | IgG subclass switch in volunteers repeatedly immunized with the full-length plasmodium falciparum Merozoite Surface Protein 1 (MSP1) |
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| Verf.angabe: | Veronika Rathay, Kristin Fürle, Viktoria Kiehl, Anne Ulmer, Michael Lanzer and Richard Thomson-Luque |
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| E-Jahr: | 2024 |
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| Jahr: | 17 February 2024 |
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| Umfang: | 19 S. |
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| Illustrationen: | Illustrationen, Diagramme |
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| Fussnoten: | Gesehen am 29.05.2024 |
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| Titel Quelle: | Enthalten in: Vaccines |
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| Ort Quelle: | Basel : MDPI, 2013 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 12(2024), 2, Artikel-ID 208, Seite 1-19 |
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| ISSN Quelle: | 2076-393X |
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| Abstract: | Vaccines are highly effective tools against infectious diseases and are also considered necessary in the fight against malaria. Vaccine-induced immunity is frequently mediated by antibodies. We have recently conducted a first-in-human clinical trial featuring SumayaVac-1, a malaria vaccine based on the recombinant, full-length merozoite surface protein 1 (MSP1FL) formulated with GLA-SE as an adjuvant. Vaccination with MSP1FL was safe and elicited sustainable IgG antibody titers that exceeded those observed in semi-immune populations from Africa. Moreover, IgG antibodies stimulated various Fc-mediated effector mechanisms associated with protection against malaria. However, these functionalities gradually waned. Here, we show that the initial two doses of SumayaVac-1 primarily induced the cytophilic subclasses IgG1 and IgG3. Unexpectedly, a shift in the IgG subclass composition occurred following the third and fourth vaccinations. Specifically, there was a progressive transition to IgG4 antibodies, which displayed a reduced capacity to engage in Fc-mediated effector functions and also exhibited increased avidity. In summary, our analysis of antibody responses to MSP1FL vaccination unveils a temporal shift towards noninflammatory IgG4 antibodies. These findings underscore the importance of considering the impact of IgG subclass composition on vaccine-induced immunity, particularly concerning Fc-mediated effector functions. This knowledge is pivotal in guiding the design of optimal vaccination strategies against malaria, informing decision making for future endeavors in this critical field. |
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| DOI: | doi:10.3390/vaccines12020208 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/vaccines12020208 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2076-393X/12/2/208 |
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| | DOI: https://doi.org/10.3390/vaccines12020208 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | <i>Plasmodium falciparum</i> |
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| | IgG subclass |
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| | malaria |
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| | MSP1 |
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| | vaccines |
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| K10plus-PPN: | 1890272310 |
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| Verknüpfungen: | → Zeitschrift |
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IgG subclass switch in volunteers repeatedly immunized with the full-length plasmodium falciparum Merozoite Surface Protein 1 (MSP1) / Rathay, Veronika [VerfasserIn]; 17 February 2024 (Online-Ressource)
