| |  Online-Ressource |
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| Verfasst von: | Schupp, Tobias [VerfasserIn]  |
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| | Abumayyaleh, Mohammad S. A. [VerfasserIn] |
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| | Weidner, Kathrin [VerfasserIn] |
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| | Lau, Felix [VerfasserIn] |
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| | Reinhardt, Marielen [VerfasserIn] |
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| | Abel, Noah [VerfasserIn] |
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| | Schmitt, Alexander [VerfasserIn] |
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| | Forner, Jan [VerfasserIn] |
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| | Ayasse, Niklas [VerfasserIn] |
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| | Bertsch, Thomas [VerfasserIn] |
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| | Akin, Muharrem [VerfasserIn] |
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| | Akın, Ibrahim [VerfasserIn] |
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| | Behnes, Michael [VerfasserIn] |
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| Titel: | Prognostic implications of type 2 Diabetes Mellitus in heart failure with mildly reduced ejection fraction |
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| Verf.angabe: | Tobias Schupp, Mohammad Abumayyaleh, Kathrin Weidner, Felix Lau, Marielen Reinhardt, Noah Abel, Alexander Schmitt, Jan Forner, Niklas Ayasse, Thomas Bertsch, Muharrem Akin, Ibrahim Akin and Michael Behnes |
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| E-Jahr: | 2024 |
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| Jahr: | 27 January 2024 |
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| Umfang: | 15 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Veröffentlicht: 27. Januar 2024 ; Gesehen am 05.06.2024 |
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| Titel Quelle: | Enthalten in: Journal of Clinical Medicine |
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| Ort Quelle: | Basel : MDPI, 2012 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 13(2024), 3, Artikel-ID 742, Seite 1-15 |
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| ISSN Quelle: | 2077-0383 |
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| Abstract: | Background: Data regarding the characterization and outcomes of diabetics with heart failure with a mildly reduced ejection fraction (HFmrEF) is scarce. This study investigates the prevalence and prognostic impact of type 2 diabetes in patients with HFmrEF. Methods: Consecutive patients with HFmrEF (i.e., left ventricular ejection fraction 41-49% and signs and/or symptoms of HF) were retrospectively included at one institution from 2016 to 2022. Patients with type 2 diabetes (dia-betics) were compared to patients without (i.e., non-diabetics). The primary endpoint was all-cause mortality at 30 months. Statistical analyses included Kaplan-Meier, multivariable Cox regression analyses and propensity score matching. Results: A total of 2169 patients with HFmrEF were included. The overall prevalence of type 2 diabetes was 36%. Diabetics had an increased risk of 30-months all-cause mortality (35.8% vs. 28.6%; HR = 1.273; 95% CI 1.092-1.483; p = 0.002), which was confirmed after multivariable adjustment (HR = 1.234; 95% CI 1.030-1.479; p = 0.022) and propensity score matching (HR = 1.265; 95% CI 1.018-1.572; p = 0.034). Diabetics had a higher risk of HF-related rehospitalization (17.8% vs. 10.7%; HR = 1.714; 95% CI 1.355-2.169; p = 0.001). Finally, the risk of all-cause mortality was increased in diabetics treated with insulin (40.7% vs. 33.1%; log-rank p = 0.029), whereas other anti-diabetic pharmacotherapies had no prognostic impact in HFmrEF. Conclusions: Type 2 diabetes is common and independently associated with adverse long-term prognosis in patients with HFmrEF. |
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| DOI: | doi:10.3390/jcm13030742 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/jcm13030742 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2077-0383/13/3/742 |
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| | DOI: https://doi.org/10.3390/jcm13030742 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | diabetes mellitus |
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| | heart failure with mildly reduced ejection fraction |
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| | HFmrEF |
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| | mortality |
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| K10plus-PPN: | 1890708615 |
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| Verknüpfungen: | → Zeitschrift |
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Prognostic implications of type 2 Diabetes Mellitus in heart failure with mildly reduced ejection fraction / Schupp, Tobias [VerfasserIn]; 27 January 2024 (Online-Ressource)
