Tumor neurobiology in the pathogenesis and therapy of head and neck cancer

• Verfasst von: Liang, Siyuan [VerfasserIn]
• Verfasst von: Heß, Jochen [VerfasserIn]
• Titel: Tumor neurobiology in the pathogenesis and therapy of head and neck cancer
• Verf.angabe: Siyuan Liang and Jochen Hess
• E-Jahr: 2024
• Jahr: 30 January 2024
• Umfang: 17 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 06.06.2024
• Titel Quelle: Enthalten in: Cells
• Ort Quelle: Basel : MDPI, 2012
• Jahr Quelle: 2024
• Band/Heft Quelle: 13(2024), 3, Artikel-ID 256, Seite 1-17
• ISSN Quelle: 2073-4409
• DOI: doi:10.3390/cells13030256
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: head and neck cancer
• Sach-SW: nerve-cancer crosstalk
• Sach-SW: TME
• Sach-SW: tumor neurobiology
• K10plus-PPN: 1890802204

Abstract

The neurobiology of tumors has attracted considerable interest from clinicians and scientists and has become a multidisciplinary area of research. Neural components not only interact with tumor cells but also influence other elements within the TME, such as immune cells and vascular components, forming a polygonal relationship to synergistically facilitate tumor growth and progression. This review comprehensively summarizes the current state of the knowledge on nerve-tumor crosstalk in head and neck cancer and discusses the potential underlying mechanisms. Several mechanisms facilitating nerve-tumor crosstalk are covered, such as perineural invasion, axonogenesis, neurogenesis, neural reprogramming, and transdifferentiation, and the reciprocal interactions between the nervous and immune systems in the TME are also discussed in this review. Further understanding of the nerve-tumor crosstalk in the TME of head and neck cancer may provide new nerve-targeted treatment options and help improve clinical outcomes for patients.