IL-1β knockout increases the intestinal abundancy of Akkermansia muciniphila

• Verfasst von: Bechberger, Maren [VerfasserIn]
• Verfasst von: Eigenbrod, Tatjana [VerfasserIn]
• Verfasst von: Boutin, Sébastien [VerfasserIn]
• Verfasst von: Heeg, Klaus [VerfasserIn]
• Verfasst von: Bode, K. A. [VerfasserIn]
• Titel: IL-1β knockout increases the intestinal abundancy of Akkermansia muciniphila
• Verf.angabe: M. Bechberger, T. Eigenbrod, S. Boutin, K. Heeg and K.A. Bode
• E-Jahr: 2023
• Jahr: 1 December 2023
• Umfang: 10 S.
• Illustrationen: Illustrationen
• Fussnoten: Online veröffentlicht: 1. September 2023 ; Gesehen am 06.06.2024
• Titel Quelle: Enthalten in: Beneficial microbes
• Ort Quelle: Wageningen : Wageningen Academic Publ., 2010
• Jahr Quelle: 2023
• Band/Heft Quelle: 14(2023), 4 vom: Dez., Seite 361-370
• ISSN Quelle: 1876-2891
• DOI: doi:10.1163/18762891-20220042
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Akkermansia muciniphila
• Sach-SW: angiogenin 4
• Sach-SW: IL-1β
• Sach-SW: IL-1β knockout mouse
• Sach-SW: microbiome
• K10plus-PPN: 1890817139

Abstract

Abstract The proinflammatory cytokine interleukin-1β (IL-1β) is known to be upregulated in patients suffering from metabolic syndrome. IL-1β contributes to insulin resistance in obesity and type 2 diabetes, yet its influence on the intestinal microbiome is incompletely understood. The data presented here demonstrate that mice genetically deficient in IL-1β show a specific alteration of intestinal colonisation of a small group of bacteria. Especially Akkermansia muciniphila, a bacterium reported to be inversely associated with obesity, diabetes, cardiometabolic diseases and low-grade inflammation, showed increased colonisation in IL-1β knockout mice. In comparative microarray analysis from mucus scrapings of the colon mucosa of IL-1β knockout and wildtype mice, angiogenin 4 mRNA was strongly reduced in IL-1β knockout animals. Since the presence of angiogenin 4 in the culture medium showed a significant growth inhibition on A. muciniphila which was not detectable for other bacteria tested, IL-1β induced expression of angiogenin 4 is a strong candidate to be responsible for the IL-1β induced suppression of A. muciniphila colonisation. Thus, the data presented here indicate that IL-1β might be the lacking link between inflammation and suppression of A. muciniphila abundance as observed in a variety of chronic inflammatory disorders.