Phenotyping of COPD with MRI in comparison to same-day CT in a multi-centre trial

• Verfasst von: Nauck, Sebastian [VerfasserIn]
• Verfasst von: Pohl, Moritz [VerfasserIn]
• Verfasst von: Jobst, Bertram [VerfasserIn]
• Verfasst von: Melzig, Claudius [VerfasserIn]
• Verfasst von: Meredig, Hagen [VerfasserIn]
• Verfasst von: Weinheimer, Oliver [VerfasserIn]
• Verfasst von: Triphan, Simon M. F. [VerfasserIn]
• Verfasst von: Stackelberg, Oyunbileg von [VerfasserIn]
• Verfasst von: Konietzke, Philip [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Heußel, Claus Peter [VerfasserIn]
• Verfasst von: Wielpütz, Mark Oliver [VerfasserIn]
• Verfasst von: Biederer, Jürgen [VerfasserIn]
• Titel: Phenotyping of COPD with MRI in comparison to same-day CT in a multi-centre trial
• Verf.angabe: Sebastian Nauck, Moritz Pohl, Bertram J. Jobst, Claudius Melzig, Hagen Meredig, Oliver Weinheimer, Simon Triphan, Oyunbileg von Stackelberg, Philip Konietzke, Hans-Ulrich Kauczor, Claus P. Heußel, Mark O. Wielpütz, Jürgen Biederer and on behalf of the COSYCONET Study Group
• E-Jahr: 2024
• Jahr: 12 February 2024
• Umfang: 13 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 12.06.2024
• Titel Quelle: Enthalten in: European radiology
• Ort Quelle: Berlin : Springer, 1991
• Jahr Quelle: 2024
• Band/Heft Quelle: 34(2024), 9, Seite 5597-5609
• ISSN Quelle: 1432-1084
• ISSN Quelle: 1613-3757
• DOI: doi:10.1007/s00330-024-10610-0
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Chronic obstructive pulmonary disease
• Sach-SW: Computed tomography
• Sach-SW: Magnetic resonance imaging
• Sach-SW: Pulmonary emphysema
• K10plus-PPN: 1891107089

Abstract

Objectives: A prospective, multi-centre study to evaluate concordance of morphologic lung MRI and CT in chronic obstructive pulmonary disease (COPD) phenotyping for airway disease and emphysema. Methods: A total of 601 participants with COPD from 15 sites underwent same-day morpho-functional chest MRI and paired inspiratory-expiratory CT. Two readers systematically scored bronchial wall thickening, bronchiectasis, centrilobular nodules, air trapping and lung parenchyma defects in each lung lobe and determined COPD phenotype. A third reader acted as adjudicator to establish consensus. Inter-modality and inter-reader agreement were assessed using Cohen’s kappa (im-κ and ir-κ). Results: The mean combined MRI score for bronchiectasis/bronchial wall thickening was 4.5/12 (CT scores, 2.2/12 for bronchiectasis and 6/12 for bronchial wall thickening; im-κ, 0.04–0.3). Expiratory right/left bronchial collapse was observed in 51 and 47/583 on MRI (62 and 57/599 on CT; im-κ, 0.49–0.52). Markers of small airways disease on MRI were 0.15/12 for centrilobular nodules (CT, 0.34/12), 0.94/12 for air trapping (CT, 0.9/12) and 7.6/12 for perfusion deficits (CT, 0.37/12 for mosaic attenuation; im-κ, 0.1–0.41). The mean lung defect score on MRI was 1.3/12 (CT emphysema score, 5.8/24; im-κ, 0.18–0.26). Airway-/emphysema/mixed COPD phenotypes were assigned in 370, 218 and 10 of 583 cases on MRI (347, 218 and 34 of 599 cases on CT; im-κ, 0.63). For all examined features, inter-reader agreement on MRI was lower than on CT. Conclusion: Concordance of MRI and CT for phenotyping of COPD in a multi-centre setting was substantial with variable inter-modality and inter-reader concordance for single diagnostic key features. Clinical relevance statement: MRI of lung morphology may well serve as a radiation-free imaging modality for COPD in scientific and clinical settings, given that its potential and limitations as shown here are carefully considered.