Effects of Ionizing radiation on Cardiac Implantable Electronic Devices (CIEDs) in patients with esophageal cancer undergoing radiotherapy

• Verfasst von: Uzun, Davut D. [VerfasserIn]
• Verfasst von: Salatzki, Janek [VerfasserIn]
• Verfasst von: Xynogalos, Panagiotis [VerfasserIn]
• Verfasst von: Frey, Norbert [VerfasserIn]
• Verfasst von: Debus, Jürgen [VerfasserIn]
• Verfasst von: Lang, Kristin [VerfasserIn]
• Titel: Effects of Ionizing radiation on Cardiac Implantable Electronic Devices (CIEDs) in patients with esophageal cancer undergoing radiotherapy
• Titelzusatz: a pilot study
• Verf.angabe: Davut D. Uzun, Janek Salatzki, Panagiotis Xynogalos, Norbert Frey, Juergen Debus and Kristin Lang
• E-Jahr: 2024
• Jahr: 28 January 2024
• Umfang: 11 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 12.06.2024
• Titel Quelle: Enthalten in: Cancers
• Ort Quelle: Basel : MDPI, 2009
• Jahr Quelle: 2024
• Band/Heft Quelle: 16(2024), 3, Artikel-ID 555, Seite 1-11
• ISSN Quelle: 2072-6694
• DOI: doi:10.3390/cancers16030555
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: cardiac devices
• Sach-SW: esophageal cancer
• Sach-SW: radiotherapy
• Sach-SW: toxicity
• K10plus-PPN: 1891113550

Abstract

(1) Background: The prevalence of cancer patients relying on cardiac implantable electronic device (CIED) is steadily rising. The aim of this study was to evaluate RT-related malfunctions of CIEDs. (2) Methods: We retrospectively analyze sixteen patients with esophageal cancer who were treated with radiotherapy between 2012 and 2022 at the University Hospital Heidelberg. All patients underwent systemic evaluation including pre-therapeutic cardiological examinations of the CIED functionality and after every single irradiation. (3) Results: Sixteen patients, predominantly male (14) with a mean age of 77 (range: 56-85) years were enrolled. All patients received 28 fractions of radiotherapy with a cumulative total dose 58.8 Gy. The mean maximum dose at the CIEDs was 1.8 Gy. Following radiotherapy and during the one-year post-radiation follow-up period, there were no registered events associated with the treatment in this evaluation. (4) Conclusion: The study did not observe any severe CIED malfunctions following each radiation fraction or after completion of RT. Strict selection of photon energy and alignment with manufacturer-recommended dose limits appear to be important. Our study showed no major differences in the measured values of the pacing threshold, sensing threshold and lead impedance after RT.