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Verfasst von:Zaharia, Oana-Patricia [VerfasserIn]   i
 Antoniou, Sofia [VerfasserIn]   i
 Bobrov, Pavel [VerfasserIn]   i
 Karusheva, Yanislava [VerfasserIn]   i
 Bódis, Kálmán [VerfasserIn]   i
 Kupriyanova, Yuliya [VerfasserIn]   i
 Schrauwen-Hinderling, Vera [VerfasserIn]   i
 Gastaldelli, Amalia [VerfasserIn]   i
 Szendrödi, Julia [VerfasserIn]   i
 Wagner, Robert [VerfasserIn]   i
 Burkart, Volker [VerfasserIn]   i
 Roden, Michael [VerfasserIn]   i
Titel:Reduced insulin clearance differently relates to increased liver lipid content and worse glycemic control in recent-onset type 2 and type 1 Diabetes
Verf.angabe:Oana-Patricia Zaharia, Sofia Antoniou, Pavel Bobrov, Yanislava Karusheva, Kálmán Bódis, Yuliya Kupriyanova, Vera Schrauwen-Hinderling, Amalia Gastaldelli, Julia Szendroedi, Robert Wagner, Volker Burkart, and Michael Roden, for the GDS Group
E-Jahr:2023
Jahr:December 2023
Umfang:9 S.
Illustrationen:Illustrationen
Fussnoten:Zuerst veröffentlicht: 24. Oktober 2023 ; Gesehen am 12.06.2024
Titel Quelle:Enthalten in: Diabetes care
Ort Quelle:Alexandria, Va. : Assoc., 1978
Jahr Quelle:2023
Band/Heft Quelle:46(2023), 12 vom: Dez., Seite 2232-2239
ISSN Quelle:1935-5548
Abstract:Diabetes may feature impaired insulin kinetics, which could be aggravated by altered hepatic metabolism and glycemic control. Thus, we examined insulin clearance and its possible determinants in individuals with recent-onset diabetes.Participants of the German Diabetes Study (GDS) with type 1 diabetes (T1D) (n = 306), type 2 diabetes (T2D) (n = 489), or normal glucose tolerance (control [CON]) (n = 167) underwent hyperinsulinemic-euglycemic clamps for assessment of whole-body insulin sensitivity (M value) and insulin clearance (ICCLAMP). Insulin clearance rates were further calculated during intravenous glucose tolerance tests (ICIVGTT) and mixed-meal tests (ICMMT). Hepatocellular lipid content (HCL) was quantified with 1H-MRS.Both T1D and T2D groups had lower ICCLAMP (0.12 ± 0.07 and 0.21 ± 0.06 vs. 0.28 ± 0.14 arbitrary units [a.u.], respectively, all P < 0.05) and ICMMT (0.71 ± 0.35 and 0.99 ± 0.33 vs. 1.20 ± 0.36 a.u., all P < 0.05) than CON. In T1D, ICCLAMP, ICIVGTT, and ICMMT correlated negatively with HbA1c (all P < 0.05). M value correlated positively with ICIVGTT in CON and T2D (r = 0.199 and r = 0.178, P < 0.05) and with ICMMT in CON (r = 0.176, P < 0.05). HCL negatively associated with ICIVGTT and ICMMT in T2D (r = −0.005 and r = −0.037) and CON (r = −0.127 and r = −0.058, all P < 0.05). In line, T2D or CON subjects with steatosis featured lower ICMMT than those without steatosis (both P < 0.05).Insulin clearance is reduced in both T1D and T2D within the first year after diagnosis but correlates negatively with liver lipid content rather in T2D. Moreover, insulin clearance differently associates with glycemic control and insulin sensitivity in each diabetes type, which may suggest specific mechanisms affecting insulin kinetics.
DOI:doi:10.2337/dc23-1267
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.2337/dc23-1267
 DOI: https://doi.org/10.2337/dc23-1267
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1891115235
Verknüpfungen:→ Zeitschrift

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