| Online-Ressource |
Verfasst von: | Wang, Lixue [VerfasserIn]  |
| Wang, Guosheng [VerfasserIn]  |
| Mao, Wenjun [VerfasserIn]  |
| Chen, Yundi [VerfasserIn]  |
| Rahman, Md Mofizur [VerfasserIn]  |
| Zhu, Chuandong [VerfasserIn]  |
| Prisinzano, Peter M. [VerfasserIn]  |
| Kong, Bo [VerfasserIn]  |
| Wang, Jing [VerfasserIn]  |
| Lee, Luke P. [VerfasserIn]  |
| Wan, Yuan [VerfasserIn]  |
Titel: | Bioinspired engineering of fusogen and targeting moiety equipped nanovesicles |
Verf.angabe: | Lixue Wang, Guosheng Wang, Wenjun Mao, Yundi Chen, Md Mofizur Rahman, Chuandong Zhu, Peter M. Prisinzano, Bo Kong, Jing Wang, Luke P. Lee & Yuan Wan |
E-Jahr: | 2023 |
Jahr: | 08 June 2023 |
Umfang: | 12 S. |
Illustrationen: | Illustrationen |
Fussnoten: | Gesehen am 13.06.2024 |
Titel Quelle: | Enthalten in: Nature Communications |
Ort Quelle: | [London] : Springer Nature, 2010 |
Jahr Quelle: | 2023 |
Band/Heft Quelle: | 14(2023), Artikel-ID 3366, Seite 1-12 |
ISSN Quelle: | 2041-1723 |
Abstract: | Cell-derived small extracellular vesicles have been exploited as potent drug vehicles. However, significant challenges hamper their clinical translation, including inefficient cytosolic delivery, poor target-specificity, low yield, and inconsistency in production. Here, we report a bioinspired material, engineered fusogen and targeting moiety co-functionalized cell-derived nanovesicle (CNV) called eFT-CNV, as a drug vehicle. We show that universal eFT-CNVs can be produced by extrusion of genetically modified donor cells with high yield and consistency. We demonstrate that bioinspired eFT-CNVs can efficiently and selectively bind to targets and trigger membrane fusion, fulfilling endo-lysosomal escape and cytosolic drug delivery. We find that, compared to counterparts, eFT-CNVs significantly improve the treatment efficacy of drugs acting on cytosolic targets. We believe that our bioinspired eFT-CNVs will be promising and powerful tools for nanomedicine and precision medicine. |
DOI: | doi:10.1038/s41467-023-39181-2 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41467-023-39181-2 |
| Volltext: https://www.nature.com/articles/s41467-023-39181-2 |
| DOI: https://doi.org/10.1038/s41467-023-39181-2 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Cryoelectron microscopy |
| Drug delivery systems |
| Extracellular vesicles |
| Nanomedicine |
K10plus-PPN: | 189120596X |
Verknüpfungen: | → Zeitschrift |
Bioinspired engineering of fusogen and targeting moiety equipped nanovesicles / Wang, Lixue [VerfasserIn]; 08 June 2023 (Online-Ressource)