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| Verfasst von: | Wang, Lixue [VerfasserIn]  |
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| | Wang, Guosheng [VerfasserIn] |
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| | Mao, Wenjun [VerfasserIn] |
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| | Chen, Yundi [VerfasserIn] |
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| | Rahman, Md Mofizur [VerfasserIn] |
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| | Zhu, Chuandong [VerfasserIn] |
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| | Prisinzano, Peter M. [VerfasserIn] |
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| | Kong, Bo [VerfasserIn] |
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| | Wang, Jing [VerfasserIn] |
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| | Lee, Luke P. [VerfasserIn] |
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| | Wan, Yuan [VerfasserIn] |
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| Titel: | Bioinspired engineering of fusogen and targeting moiety equipped nanovesicles |
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| Verf.angabe: | Lixue Wang, Guosheng Wang, Wenjun Mao, Yundi Chen, Md Mofizur Rahman, Chuandong Zhu, Peter M. Prisinzano, Bo Kong, Jing Wang, Luke P. Lee & Yuan Wan |
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| E-Jahr: | 2023 |
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| Jahr: | 08 June 2023 |
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| Umfang: | 12 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 13.06.2024 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 14(2023), Artikel-ID 3366, Seite 1-12 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Cell-derived small extracellular vesicles have been exploited as potent drug vehicles. However, significant challenges hamper their clinical translation, including inefficient cytosolic delivery, poor target-specificity, low yield, and inconsistency in production. Here, we report a bioinspired material, engineered fusogen and targeting moiety co-functionalized cell-derived nanovesicle (CNV) called eFT-CNV, as a drug vehicle. We show that universal eFT-CNVs can be produced by extrusion of genetically modified donor cells with high yield and consistency. We demonstrate that bioinspired eFT-CNVs can efficiently and selectively bind to targets and trigger membrane fusion, fulfilling endo-lysosomal escape and cytosolic drug delivery. We find that, compared to counterparts, eFT-CNVs significantly improve the treatment efficacy of drugs acting on cytosolic targets. We believe that our bioinspired eFT-CNVs will be promising and powerful tools for nanomedicine and precision medicine. |
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| DOI: | doi:10.1038/s41467-023-39181-2 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41467-023-39181-2 |
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| | Volltext: https://www.nature.com/articles/s41467-023-39181-2 |
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| | DOI: https://doi.org/10.1038/s41467-023-39181-2 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cryoelectron microscopy |
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| | Drug delivery systems |
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| | Extracellular vesicles |
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| | Nanomedicine |
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| K10plus-PPN: | 189120596X |
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| Verknüpfungen: | → Zeitschrift |
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Bioinspired engineering of fusogen and targeting moiety equipped nanovesicles / Wang, Lixue [VerfasserIn]; 08 June 2023 (Online-Ressource)
