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Verfasst von:Conticini, Edoardo [VerfasserIn]   i
 Hellmich, Bernhard [VerfasserIn]   i
 Frediani, B [VerfasserIn]   i
 Csernok, E [VerfasserIn]   i
 Löffler, Christian [VerfasserIn]   i
Titel:Utility of serum complement factors C3 and C4 as biomarkers during therapeutic management of giant cell arteritis
Verf.angabe:E Conticini, B Hellmich, B Frediani, E Csernok and C Löffler
Jahr:2023
Umfang:7 S.
Fussnoten:Online veröffentlicht: 06. April 2022 ; Gesehen am 17.06.2024
Titel Quelle:Enthalten in: Scandinavian journal of rheumatology
Ort Quelle:Abingdon : Taylor & Francis, 1972
Jahr Quelle:2023
Band/Heft Quelle:52(2023), 3, Seite 276-282
ISSN Quelle:1502-7732
Abstract:There is a strong unmet need for biomarkers in giant cell arteritis (GCA), as C-reactive protein (CRP) may be unreliable in patients treated with Tocilizumab (TCZ). We aimed to assess whether C3 and C4 are useful biomarkers in GCA patients, particularly in those treated with TCZ. We retrospectively enrolled all patients who underwent C3 and C4 measurement at baseline. All patients were evaluated at 3, 6, 12, and 24 months after diagnosis, as part of routine follow-up. Two assessments after the end of the observational period, in case of further relapses, were also included. At baseline, mean ± sd levels (mg/dL) of C3 (133 ± 28.99) and C4 (25.9 ± 9.04) were within normal ranges. During follow-up, C3 and C4 decreased in patients attaining remission (107.07 ± 19.86, p = 0.0006; 19.86 ± 10.27, p = 0.01, respectively) and sustained remission (95.85 ± 18.04, p = 0.001; 15.61 ± 9.75, p = 0.006). In TCZ-treated patients, even stronger decreases in C3 (83.11 ± 19.66, p = 0.001) and C4 (8.26 ± 3.83, p < 0.0001) were observed, and their values were not correlated with CRP or erythrocyte sedimentation rate. C3 and C4 do not seem useful in the diagnosis of GCA, as normal values do not rule out active vasculitis. However, C3 and C4 correlate with disease activity. As the low C4 levels found in TCZ-treated patients are not correlated with CRP, C4 should be evaluated as a potential biomarker of disease activity and treatment response.
DOI:doi:10.1080/03009742.2022.2047311
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1080/03009742.2022.2047311
 Volltext: https://www.tandfonline.com/doi/full/10.1080/03009742.2022.2047311
 DOI: https://doi.org/10.1080/03009742.2022.2047311
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1891383000
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