| |  Online-Ressource |
|---|
| Verfasst von: | Reinecke, Raphael [VerfasserIn]  |
|---|
| | Jahnke, Kolja [VerfasserIn] |
|---|
| | Foltyn-Dumitru, Martha [VerfasserIn] |
|---|
| | Lachner, Karsten [VerfasserIn] |
|---|
| | Armbrust, Moritz [VerfasserIn] |
|---|
| | Weber, Katharina J. [VerfasserIn] |
|---|
| | Zeiner, Pia S. [VerfasserIn] |
|---|
| | Czabanka, Marcus [VerfasserIn] |
|---|
| | Brunnberg, Uta [VerfasserIn] |
|---|
| | Hartmann, Sylvia [VerfasserIn] |
|---|
| | Steinbach, Joachim P. [VerfasserIn] |
|---|
| | Ronellenfitsch, Michael W. [VerfasserIn] |
|---|
| Titel: | Intrathecal IgM synthesis as a diagnostic marker in patients with suspected CNS lymphoma |
|---|
| Verf.angabe: | Raphael Reinecke, Kolja Jahnke, Martha Foltyn-Dumitru, Karsten Lachner, Moritz Armbrust, Katharina J. Weber, Pia S. Zeiner, Marcus Czabanka, Uta Brunnberg, Sylvia Hartmann, Joachim P. Steinbach, Michael W. Ronellenfitsch |
|---|
| E-Jahr: | 2024 |
|---|
| Jahr: | June 2024 |
|---|
| Umfang: | 11 S. |
|---|
| Illustrationen: | Illustrationen |
|---|
| Fussnoten: | Zuerst veröffentlicht: 08. Februar 2024 ; Gesehen am 18.06.2024 |
|---|
| Titel Quelle: | Enthalten in: Journal of neurochemistry |
|---|
| Ort Quelle: | Oxford : Wiley-Blackwell, 1956 |
|---|
| Jahr Quelle: | 2024 |
|---|
| Band/Heft Quelle: | 168(2024), 6 vom: Juni, Seite 1157-1167 |
|---|
| ISSN Quelle: | 1471-4159 |
|---|
| Abstract: | For CNS lymphomas (CNSL), there is a high need for minimally invasive and easily obtainable diagnostic markers. Intrathecal IgM synthesis can easily be determined in routine CSF diagnostics. The aim of this study was to systematically investigate the diagnostic potential of intrathecal IgM synthesis in primary and secondary CNSL (PCNSL and SCNSL). In this retrospective study, patients with a biopsy-proven diagnosis of PCNSL or SCNSL were compared with patients with other neurological diseases in whom CNSL was initially the primary radiological differential diagnosis based on MRI. Sensitivity and specificity of intrathecal IgM synthesis were calculated using receiver operating characteristic curves. Seventy patients with CNSL were included (49 PCNSL and 21 SCNSL) and compared to 70 control patients. The sensitivity and specificity for the diagnosis of CNSL were 49% and 87%, respectively, for the entire patient population and 66% and 91% after selection for cases with tumor access to the CSF system and isolated intrathecal IgM synthesis. In cases with MRI-based radiological suspicion of CNSL, intrathecal IgM synthesis has good specificity but limited sensitivity. Because of its low-threshold availability, analysis of intrathecal IgM synthesis has the potential to lead to higher diagnostic accuracy, especially in resource-limited settings, and deserves further study. |
|---|
| DOI: | doi:10.1111/jnc.16069 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1111/jnc.16069 |
|---|
| | kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/jnc.16069 |
|---|
| | DOI: https://doi.org/10.1111/jnc.16069 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | biomarker |
|---|
| | CNS lymphoma |
|---|
| | immunoglobulin synthesis |
|---|
| K10plus-PPN: | 1891405969 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Intrathecal IgM synthesis as a diagnostic marker in patients with suspected CNS lymphoma / Reinecke, Raphael [VerfasserIn]; June 2024 (Online-Ressource)
