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| Verfasst von: | Engblom, Camilla [VerfasserIn]  |
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| | Thrane, Kim [VerfasserIn] |
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| | Lin, Qirong [VerfasserIn] |
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| | Andersson, Alma [VerfasserIn] |
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| | Toosi, Hosein [VerfasserIn] |
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| | Chen, Xinsong [VerfasserIn] |
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| | Steiner, Embla [VerfasserIn] |
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| | Lu, Chang [VerfasserIn] |
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| | Mantovani, Giulia [VerfasserIn] |
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| | Hagemann-Jensen, Michael [VerfasserIn] |
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| | Saarenpää, Sami [VerfasserIn] |
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| | Jangard, Mattias [VerfasserIn] |
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| | Sáez Rodríguez, Julio [VerfasserIn] |
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| | Michaëlsson, Jakob [VerfasserIn] |
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| | Hartman, Johan [VerfasserIn] |
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| | Lagergren, Jens [VerfasserIn] |
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| | Mold, Jeff E. [VerfasserIn] |
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| | Lundeberg, Joakim [VerfasserIn] |
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| | Frisén, Jonas [VerfasserIn] |
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| Titel: | Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics |
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| Verf.angabe: | Camilla Engblom, Kim Thrane, Qirong Lin, Alma Andersson, Hosein Toosi, Xinsong Chen, Embla Steiner, Chang Lu, Giulia Mantovani, Michael Hagemann-Jensen, Sami Saarenpää, Mattias Jangard, Julio Saez-Rodriguez, Jakob Michaëlsson, Johan Hartman, Jens Lagergren, Jeff E. Mold, Joakim Lundeberg, Jonas Frisén |
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| E-Jahr: | 2023 |
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| Jahr: | 8 Dec 2023 |
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| Umfang: | 17 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 18.06.2024 |
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| Titel Quelle: | Enthalten in: Science |
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| Ort Quelle: | Washington, DC : American Association for the Advancement of Science, 1880 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 382(2023), 6675 vom: Dez., Artikel-ID eadf8486, Seite 1-17 |
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| ISSN Quelle: | 1095-9203 |
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| Abstract: | The spatial distribution of lymphocyte clones within tissues is critical to their development, selection, and expansion. We have developed spatial transcriptomics of variable, diversity, and joining (VDJ) sequences (Spatial VDJ), a method that maps B cell and T cell receptor sequences in human tissue sections. Spatial VDJ captures lymphocyte clones that match canonical B and T cell distributions and amplifies clonal sequences confirmed by orthogonal methods. We found spatial congruency between paired receptor chains, developed a computational framework to predict receptor pairs, and linked the expansion of distinct B cell clones to different tumor-associated gene expression programs. Spatial VDJ delineates B cell clonal diversity and lineage trajectories within their anatomical niche. Thus, Spatial VDJ captures lymphocyte spatial clonal architecture across tissues, providing a platform to harness clonal sequences for therapy. |
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| DOI: | doi:10.1126/science.adf8486 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1126/science.adf8486 |
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| | Volltext: https://www.science.org/doi/10.1126/science.adf8486 |
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| | DOI: https://doi.org/10.1126/science.adf8486 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1891429779 |
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| Verknüpfungen: | → Zeitschrift |
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Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics / Engblom, Camilla [VerfasserIn]; 8 Dec 2023 (Online-Ressource)
