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| Verfasst von: | Wang, Mengfei [VerfasserIn]  |
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| | Kono, Masaya [VerfasserIn] |
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| | Yamaguchi, Yusaku [VerfasserIn] |
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| | Islam, Jahidul [VerfasserIn] |
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| | Shoji, Sunao [VerfasserIn] |
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| | Kitagawa, Yuichi [VerfasserIn] |
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| | Fushimi, Koji [VerfasserIn] |
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| | Watanabe, Sora [VerfasserIn] |
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| | Matsuba, Go [VerfasserIn] |
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| | Yamamoto, Akihisa [VerfasserIn] |
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| | Tanaka, Motomu [VerfasserIn] |
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| | Tsuda, Masumi [VerfasserIn] |
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| | Tanaka, Shinya [VerfasserIn] |
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| | Hasegawa, Yasuchika [VerfasserIn] |
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| Titel: | Structure-changeable luminescent Eu(III) complex as a human cancer grade probing system for brain tumor diagnosis |
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| Verf.angabe: | Mengfei Wang, Masaya Kono, Yusaku Yamaguchi, Jahidul Islam, Sunao Shoji, Yuichi Kitagawa, Koji Fushimi, Sora Watanabe, Go Matsuba, Akihisa Yamamoto, Motomu Tanaka, Masumi Tsuda, Shinya Tanaka & Yasuchika Hasegawa |
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| E-Jahr: | 2024 |
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| Jahr: | 22 January 2024 |
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| Umfang: | 8 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 21.06.2024 |
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| Titel Quelle: | Enthalten in: Scientific reports |
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| Ort Quelle: | [London] : Springer Nature, 2011 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 14(2024), Artikel-ID 778, Seite 1-8 |
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| ISSN Quelle: | 2045-2322 |
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| Abstract: | Accurate determination of human tumor malignancy is important for choosing efficient and safe therapies. Bioimaging technologies based on luminescent molecules are widely used to localize and distinguish active tumor cells. Here, we report a human cancer grade probing system (GPS) using a water-soluble and structure-changeable Eu(III) complex for the continuous detection of early human brain tumors of different malignancy grades. Time-dependent emission spectra of the Eu(III) complexes in various types of tumor cells were recorded. The radiative rate constants (kr), which depend on the geometry of the Eu(III) complex, were calculated from the emission spectra. The tendency of the kr values to vary depended on the tumor cells at different malignancy grades. Between T = 0 and T = 3 h of invasion, the kr values exhibited an increase of 4% in NHA/TS (benign grade II gliomas), 7% in NHA/TSR (malignant grade III gliomas), and 27% in NHA/TSRA (malignant grade IV gliomas). Tumor cells with high-grade malignancy exhibited a rapid upward trend in kr values. The cancer GPS employs Eu(III) emissions to provide a new diagnostic method for determining human brain tumor malignancy. |
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| DOI: | doi:10.1038/s41598-023-50138-9 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41598-023-50138-9 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41598-023-50138-9 |
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| | DOI: https://doi.org/10.1038/s41598-023-50138-9 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Diagnostic markers |
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| | Fluorescent probes |
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| K10plus-PPN: | 1892005646 |
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| Verknüpfungen: | → Zeitschrift |
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Structure-changeable luminescent Eu(III) complex as a human cancer grade probing system for brain tumor diagnosis / Wang, Mengfei [VerfasserIn]; 22 January 2024 (Online-Ressource)
