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| Verfasst von: | Burr, Stephen P. [VerfasserIn]  |
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| | Klimm, Florian [VerfasserIn] |
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| | Glynos, Angelos [VerfasserIn] |
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| | Prater, Malwina [VerfasserIn] |
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| | Sendon, Pamella [VerfasserIn] |
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| | Nash, Pavel [VerfasserIn] |
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| | Powell, Christopher A. [VerfasserIn] |
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| | Simard, Marie-Lune [VerfasserIn] |
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| | Bonekamp, Nina A. [VerfasserIn] |
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| | Charl, Julia [VerfasserIn] |
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| | Diaz, Hector [VerfasserIn] |
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| | Bozhilova, Lyuba V. [VerfasserIn] |
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| | Nie, Yu [VerfasserIn] |
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| | Zhang, Haixin [VerfasserIn] |
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| | Frison, Michele [VerfasserIn] |
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| | Falkenberg, Maria [VerfasserIn] |
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| | Jones, Nick [VerfasserIn] |
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| | Minczuk, Michal [VerfasserIn] |
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| | Stewart, James B. [VerfasserIn] |
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| | Chinnery, Patrick F. [VerfasserIn] |
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| Titel: | Cell lineage-specific mitochondrial resilience during mammalian organogenesis |
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| Verf.angabe: | Stephen P. Burr, Florian Klimm, Angelos Glynos, Malwina Prater, Pamella Sendon, Pavel Nash, Christopher A. Powell, Marie-Lune Simard, Nina A. Bonekamp, Julia Charl, Hector Diaz, Lyuba V. Bozhilova, Yu Nie, Haixin Zhang, Michele Frison, Maria Falkenberg, Nick Jones, Michal Minczuk, James B. Stewart, and Patrick F. Chinnery |
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| E-Jahr: | 2023 |
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| Jahr: | 16 March 2023 |
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| Umfang: | 18 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 23. Februar 2023,Artikelversion: 16. März 2023 ; Gesehen am 24.06.2024 |
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| Titel Quelle: | Enthalten in: Cell |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1974 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 186(2023), 6, Seite 1212-1229,[1-21] |
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| ISSN Quelle: | 1097-4172 |
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| Abstract: | Mitochondrial activity differs markedly between organs, but it is not known how and when this arises. Here we show that cell lineage-specific expression profiles involving essential mitochondrial genes emerge at an early stage in mouse development, including tissue-specific isoforms present before organ formation. However, the nuclear transcriptional signatures were not independent of organelle function. Genetically disrupting intra-mitochondrial protein synthesis with two different mtDNA mutations induced cell lineage-specific compensatory responses, including molecular pathways not previously implicated in organellar maintenance. We saw downregulation of genes whose expression is known to exacerbate the effects of exogenous mitochondrial toxins, indicating a transcriptional adaptation to mitochondrial dysfunction during embryonic development. The compensatory pathways were both tissue and mutation specific and under the control of transcription factors which promote organelle resilience. These are likely to contribute to the tissue specificity which characterizes human mitochondrial diseases and are potential targets for organ-directed treatments. |
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| DOI: | doi:10.1016/j.cell.2023.01.034 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.cell.2023.01.034 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0092867423000934 |
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| | DOI: https://doi.org/10.1016/j.cell.2023.01.034 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | mitochondria |
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| | mt-Ta |
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| | mtDNA |
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| | organogenesis |
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| | OXPHOS |
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| | RNA-seq |
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| | SCENIC |
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| | single-cell |
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| K10plus-PPN: | 1892063581 |
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| Verknüpfungen: | → Zeitschrift |
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Cell lineage-specific mitochondrial resilience during mammalian organogenesis / Burr, Stephen P. [VerfasserIn]; 16 March 2023 (Online-Ressource)
