Molecular diagnostics of hepatobiliary and pancreatic neoplasias

• Verfasst von: Longerich, Thomas [VerfasserIn]
• Verfasst von: Stenzinger, Albrecht [VerfasserIn]
• Verfasst von: Schirmacher, Peter [VerfasserIn]
• Titel: Molecular diagnostics of hepatobiliary and pancreatic neoplasias
• Verf.angabe: T. Longerich, A. Stenzinger, P. Schirmacher
• E-Jahr: 2024
• Umfang: 10 S.
• Illustrationen: Illustrationen
• Fussnoten: Online veröffentlicht am 1. März 2024 ; Gesehen am 25.06.2024
• Weitere Titel: Titel des Annual Review Issue: Molecular pathology as basis for timely cancer diagnosis and therapy
• Titel Quelle: Enthalten in: Virchows Archiv
• Ort Quelle: Berlin : Springer, 1847
• Jahr Quelle: 2024
• Band/Heft Quelle: 484(2024), 2, annual review issue vom: Feb., Seite 263-272
• ISSN Quelle: 1432-2307
• DOI: doi:10.1007/s00428-024-03744-5
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Cancer
• Sach-SW: Hepatobiliary
• Sach-SW: Molecular diagnostics
• Sach-SW: Pancreas
• Sach-SW: Personalized Medicine
• K10plus-PPN: 1892150069

Abstract

Neoplasias of the hepatopancreatobiliary tract are growing in numbers, have the poorest prognosis of all major cancer entities, and thus represent a rising clinical problem. Their molecular diagnostic has dramatically improved, contributing to tumor subtyping, definition of malignancy, and uncovering cases with hereditary predisposition. Most of all, predictive molecular testing allows to identify cases amenable to treatment with the rising number of approved targeted drugs, immune-oncological treatment, and clinical trials. In this review, the current state of molecular testing and its contribution to clinical decision-making are outlined.