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Status: Bibliographieeintrag

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Verfasst von:Sebastian, Martin [VerfasserIn]   i
 Eberhardt, Wilfried E. E. [VerfasserIn]   i
 Heyde, Eyck von der [VerfasserIn]   i
 Dörfel, Steffen [VerfasserIn]   i
 Wiegand, Jörg [VerfasserIn]   i
 Schiefer, Clemens [VerfasserIn]   i
 Losem, Christoph [VerfasserIn]   i
 Jänicke, Martina [VerfasserIn]   i
 Fleitz, Annette [VerfasserIn]   i
 Zacharias, Stefan [VerfasserIn]   i
 Kaiser-Osterhues, Anja [VerfasserIn]   i
 Hipper, Annette [VerfasserIn]   i
 Dietel, Corinna [VerfasserIn]   i
 Bleckmann, Annalen [VerfasserIn]   i
 Benkelmann, Robin [VerfasserIn]   i
 Boesche, Michael [VerfasserIn]   i
 Grah, Christian [VerfasserIn]   i
 Müller, Annette [VerfasserIn]   i
 Griesinger, Frank [VerfasserIn]   i
 Thomas, Michael [VerfasserIn]   i
Titel:Patient-reported outcomes in advanced NSCLC before and during the COVID-19 pandemic
Titelzusatz:real-world data from the German prospective CRISP Registry (AIO-TRK-0315)
Verf.angabe:Martin Sebastian, Wilfried E. E. Eberhardt, Eyck von der Heyde, Steffen Dörfel, Jörg Wiegand, Clemens Schiefer, Christoph Losem, Martina Jänicke, Annette Fleitz, Stefan Zacharias, Anja Kaiser-Osterhues, Annette Hipper, Corinna Dietel, Annalen Bleckmann, Robin Benkelmann, Michael Boesche, Christian Grah, Annette Müller, Frank Griesinger, Michael Thomas, for the CRISP Registry Group
E-Jahr:2024
Jahr:1 June 2024
Umfang:12 S.
Illustrationen:Illustrationen
Fussnoten:Zuerst veröffentlicht: 08. Februar 2024 ; Gesehen am 26.06.2024
Titel Quelle:Enthalten in: International journal of cancer
Ort Quelle:Bognor Regis : Wiley-Liss, 1966
Jahr Quelle:2024
Band/Heft Quelle:154(2024), 11 vom: Juni, Seite 1967-1978
ISSN Quelle:1097-0215
Abstract:Patients with lung cancer under treatment have been associated with a high risk of COVID-19 infection and potentially worse outcome, but real-world data on patient-reported outcomes (PROs) are rare. We assess patients' characteristics and PROs before and during the COVID-19 pandemic in an advanced non-small cell lung cancer (NSCLC) cohort in Germany. Patients with locally advanced or metastatic NSCLC from the prospective, multicentre, observational CRISP Registry (NCT02622581) were categorised as pre-pandemic (March 2019 to Feb 2020, n = 1621) and pandemic (March 2020 to Feb 2021, n = 1317). From baseline to month 15, patients' health-related quality of life (HRQoL) was assessed by FACT-L, anxiety and depression by PHQ-4. Association of pandemic status with time to deterioration (TTD) in QoL scales adjusted for potential covariates was estimated using Cox modelling. PROs were documented for 1166 patients (72%) in the pre-pandemic, 979 (74%) in the pandemic group. Almost 60% of patients were male, median age was 66 years, comorbidities occurred in 85%. Regarding HRQoL, mean-change-from-baseline plots hardly differed between both samples. Approximately 15%-21% of patients reported anxiety, about 19%-27% signs of depression. For the pandemic group, TTD was slightly, but statistically significantly, worse for the physical well-being-FACT-G subscale (HR 1.15 [95%CI 1.02-1.30]) and the anxiety-GAD-2 subscale (HR 1.14 [95%CI 1.01-1.29]). These prospectively collected real-world data provide valuable insights into PROs before and during the COVID-19 pandemic in advanced NSCLC. For the patients, the pandemic seemed to be less of a burden than the disease itself, as there was a considerable proportion of patients with anxiety and depression in both groups.
DOI:doi:10.1002/ijc.34868
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1002/ijc.34868
 kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.34868
 DOI: https://doi.org/10.1002/ijc.34868
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:cohort studies
 COVID-19
 non-small cell lung cancer
 patient-reported outcomes
 real world
K10plus-PPN:1892261480
Verknüpfungen:→ Zeitschrift

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