| Online-Ressource |
Verfasst von: | Sebastian, Martin [VerfasserIn]  |
| Eberhardt, Wilfried E. E. [VerfasserIn]  |
| Heyde, Eyck von der [VerfasserIn]  |
| Dörfel, Steffen [VerfasserIn]  |
| Wiegand, Jörg [VerfasserIn]  |
| Schiefer, Clemens [VerfasserIn]  |
| Losem, Christoph [VerfasserIn]  |
| Jänicke, Martina [VerfasserIn]  |
| Fleitz, Annette [VerfasserIn]  |
| Zacharias, Stefan [VerfasserIn]  |
| Kaiser-Osterhues, Anja [VerfasserIn]  |
| Hipper, Annette [VerfasserIn]  |
| Dietel, Corinna [VerfasserIn]  |
| Bleckmann, Annalen [VerfasserIn]  |
| Benkelmann, Robin [VerfasserIn]  |
| Boesche, Michael [VerfasserIn]  |
| Grah, Christian [VerfasserIn]  |
| Müller, Annette [VerfasserIn]  |
| Griesinger, Frank [VerfasserIn]  |
| Thomas, Michael [VerfasserIn]  |
Titel: | Patient-reported outcomes in advanced NSCLC before and during the COVID-19 pandemic |
Titelzusatz: | real-world data from the German prospective CRISP Registry (AIO-TRK-0315) |
Verf.angabe: | Martin Sebastian, Wilfried E. E. Eberhardt, Eyck von der Heyde, Steffen Dörfel, Jörg Wiegand, Clemens Schiefer, Christoph Losem, Martina Jänicke, Annette Fleitz, Stefan Zacharias, Anja Kaiser-Osterhues, Annette Hipper, Corinna Dietel, Annalen Bleckmann, Robin Benkelmann, Michael Boesche, Christian Grah, Annette Müller, Frank Griesinger, Michael Thomas, for the CRISP Registry Group |
E-Jahr: | 2024 |
Jahr: | 1 June 2024 |
Umfang: | 12 S. |
Illustrationen: | Illustrationen |
Fussnoten: | Zuerst veröffentlicht: 08. Februar 2024 ; Gesehen am 26.06.2024 |
Titel Quelle: | Enthalten in: International journal of cancer |
Ort Quelle: | Bognor Regis : Wiley-Liss, 1966 |
Jahr Quelle: | 2024 |
Band/Heft Quelle: | 154(2024), 11 vom: Juni, Seite 1967-1978 |
ISSN Quelle: | 1097-0215 |
Abstract: | Patients with lung cancer under treatment have been associated with a high risk of COVID-19 infection and potentially worse outcome, but real-world data on patient-reported outcomes (PROs) are rare. We assess patients' characteristics and PROs before and during the COVID-19 pandemic in an advanced non-small cell lung cancer (NSCLC) cohort in Germany. Patients with locally advanced or metastatic NSCLC from the prospective, multicentre, observational CRISP Registry (NCT02622581) were categorised as pre-pandemic (March 2019 to Feb 2020, n = 1621) and pandemic (March 2020 to Feb 2021, n = 1317). From baseline to month 15, patients' health-related quality of life (HRQoL) was assessed by FACT-L, anxiety and depression by PHQ-4. Association of pandemic status with time to deterioration (TTD) in QoL scales adjusted for potential covariates was estimated using Cox modelling. PROs were documented for 1166 patients (72%) in the pre-pandemic, 979 (74%) in the pandemic group. Almost 60% of patients were male, median age was 66 years, comorbidities occurred in 85%. Regarding HRQoL, mean-change-from-baseline plots hardly differed between both samples. Approximately 15%-21% of patients reported anxiety, about 19%-27% signs of depression. For the pandemic group, TTD was slightly, but statistically significantly, worse for the physical well-being-FACT-G subscale (HR 1.15 [95%CI 1.02-1.30]) and the anxiety-GAD-2 subscale (HR 1.14 [95%CI 1.01-1.29]). These prospectively collected real-world data provide valuable insights into PROs before and during the COVID-19 pandemic in advanced NSCLC. For the patients, the pandemic seemed to be less of a burden than the disease itself, as there was a considerable proportion of patients with anxiety and depression in both groups. |
DOI: | doi:10.1002/ijc.34868 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1002/ijc.34868 |
| kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.34868 |
| DOI: https://doi.org/10.1002/ijc.34868 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | cohort studies |
| COVID-19 |
| non-small cell lung cancer |
| patient-reported outcomes |
| real world |
K10plus-PPN: | 1892261480 |
Verknüpfungen: | → Zeitschrift |
Patient-reported outcomes in advanced NSCLC before and during the COVID-19 pandemic / Sebastian, Martin [VerfasserIn]; 1 June 2024 (Online-Ressource)