A synthetic sialic acid analog that is resistant to the receptor-destroying enzyme can be used by influenza C virus as a receptor determinant for infection of cells

• Verfasst von: Herrler, Georg [VerfasserIn]
• Verfasst von: Groß, Hans Jürgen [VerfasserIn]
• Verfasst von: Brossmer, Reinhard [VerfasserIn]
• Titel: A synthetic sialic acid analog that is resistant to the receptor-destroying enzyme can be used by influenza C virus as a receptor determinant for infection of cells
• Verf.angabe: Georg Herrler, Hans-Jürgen Gross, and Reinhard Brossmer
• E-Jahr: 1995
• Jahr: November 22, 1995
• Umfang: 7 S.
• Fussnoten: Elektronische Reproduktion der Druck-Ausgabe 25. Mai 2002 ; Gesehen am 27.06.2024
• Titel Quelle: Enthalten in: Biochemical and biophysical research communications
• Ort Quelle: [Amsterdam] : Elsevier B.V., 1959
• Jahr Quelle: 1995
• Band/Heft Quelle: 216(1995), 3, Seite 821-827
• ISSN Quelle: 1090-2104
• DOI: doi:10.1006/bbrc.1995.2695
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1892312492

Abstract

A synthetic sialic acid analog, N-acetyl-9-acetamido-9-deoxy-neuraminic acid, can be used by influenza C virus as a receptor determinant for attachment to cells, In contrast to the natural determinant, N-acetyl-9-O-acetylneuraminic acid, the synthetic sialic acid is resistant to the action of the receptor-destroying acetylesterase of this virus. The sialic acid analog was enzymatically transferred to the surface of Madin-Darby canine kidney cells that are resistant to infection because of a lack of receptors. Influenza C virus was able to infect the modified cells though requiring a 10-fold larger amount of the sialic acid analogue on the cell surface compared to the natural receptor determinant. The quantitative difference is accounted for mainly by a less efficient binding of influenza C virus to the analog. Thus, in our system, inactivation of the receptor by the viral esterase is not required for the initiation of an influenza C virus infection.