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| Verfasst von: | Jaikuna, Tanwiwat [VerfasserIn]  |
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| | Osorio, Eliana Vasquez [VerfasserIn] |
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| | Azria, David [VerfasserIn] |
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| | Chang-Claude, Jenny [VerfasserIn] |
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| | De Santis, Maria Carmen [VerfasserIn] |
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| | Gutiérrez-Enríquez, Sara [VerfasserIn] |
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| | van Herk, Marcel [VerfasserIn] |
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| | Hoskin, Peter [VerfasserIn] |
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| | Lambrecht, Maarten [VerfasserIn] |
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| | Lingard, Zoe [VerfasserIn] |
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| | Seibold, Petra [VerfasserIn] |
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| | Seoane, Alejandro [VerfasserIn] |
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| | Sperk, Elena [VerfasserIn] |
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| | Symonds, R Paul [VerfasserIn] |
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| | Talbot, Christopher J. [VerfasserIn] |
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| | Rancati, Tiziana [VerfasserIn] |
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| | Rattay, Tim [VerfasserIn] |
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| | Reyes, Victoria [VerfasserIn] |
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| | Rosenstein, Barry S. [VerfasserIn] |
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| | de Ruysscher, Dirk [VerfasserIn] |
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| | Vega, Ana [VerfasserIn] |
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| | Veldeman, Liv [VerfasserIn] |
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| | Webb, Adam [VerfasserIn] |
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| | West, Catharine M. L. [VerfasserIn] |
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| | Aznar, Marianne C. [VerfasserIn] |
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| Titel: | Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy |
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| Verf.angabe: | Tanwiwat Jaikuna, Eliana Vasquez Osorio, David Azria, Jenny Chang-Claude, Maria Carmen De Santis, Sara Gutiérrez-Enríquez, Marcel van Herk, Peter Hoskin, Maarten Lambrecht, Zoe Lingard, Petra Seibold, Alejandro Seoane, Elena Sperk, R Paul Symonds, Christopher J. Talbot, Tiziana Rancati, Tim Rattay, Victoria Reyes, Barry S. Rosenstein, Dirk de Ruysscher, Ana Vega, Liv Veldeman, Adam Webb, Catharine M.L. West, Marianne C. Aznar |
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| E-Jahr: | 2023 |
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| Jahr: | December 2023 |
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| Umfang: | 9 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 11. September 2023, Artikelversion: 13. September 2023 ; Gesehen am 28.06.2024 |
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| Titel Quelle: | Enthalten in: The breast |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 1992 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 72(2023) vom: Dez., Artikel-ID 103578, Seite 1-9 |
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| ISSN Quelle: | 1532-3080 |
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| Abstract: | Background - Normal tissue complication probability (NTCP) models can be useful to estimate the risk of fibrosis after breast-conserving surgery (BCS) and radiotherapy (RT) to the breast. However, they are subject to uncertainties. We present the impact of contouring variation on the prediction of fibrosis. - Materials and methods - 280 breast cancer patients treated BCS-RT were included. Nine Clinical Target Volume (CTV) contours were created for each patient: i) CTV_crop (reference), cropped 5 mm from the skin and ii) CTV_skin, uncropped and including the skin, iii) segmenting the 95% isodose (Iso95%) and iv) 3 different auto-contouring atlases generating uncropped and cropped contours (Atlas_skin/Atlas_crop). To illustrate the impact of contour variation on NTCP estimates, we applied two equations predicting fibrosis grade ≥ 2 at 5 years, based on Lyman-Kutcher-Burman (LKB) and Relative Seriality (RS) models, respectively, to each contour. Differences were evaluated using repeated-measures ANOVA. For completeness, the association between observed fibrosis events and NTCP estimates was also evaluated using logistic regression. - Results - There were minimal differences between contours when the same contouring approach was followed (cropped and uncropped). CTV_skin and Atlas_skin contours had lower NTCP estimates (−3.92%, IQR 4.00, p < 0.05) compared to CTV_crop. No significant difference was observed for Atlas_crop and Iso95% contours compared to CTV_crop. For the whole cohort, NTCP estimates varied between 5.3% and 49.5% (LKB) or 2.2% and 49.6% (RS) depending on the choice of contours. NTCP estimates for individual patients varied by up to a factor of 4. Estimates from “skin” contours showed higher agreement with observed events. - Conclusion - Contour variations can lead to significantly different NTCP estimates for breast fibrosis, highlighting the importance of standardising breast contours before developing and/or applying NTCP models. |
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| DOI: | doi:10.1016/j.breast.2023.103578 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.breast.2023.103578 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S0960977623005520 |
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| | DOI: https://doi.org/10.1016/j.breast.2023.103578 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Breast cancer |
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| | Fibrosis |
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| | Inter-observer variation |
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| | Late effects |
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| | NTCP modelling |
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| | Radiotherapy |
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| K10plus-PPN: | 1892423944 |
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| Verknüpfungen: | → Zeitschrift |
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Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy / Jaikuna, Tanwiwat [VerfasserIn]; December 2023 (Online-Ressource)
