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| Verfasst von: | Wieder, Thomas [VerfasserIn]  |
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| | Geilen, Christoph C [VerfasserIn] |
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| | Kolter, Thomas [VerfasserIn] |
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| | Sadeghlar, Farsaneh [VerfasserIn] |
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| | Sandhoff, Konrad [VerfasserIn] |
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| | Brossmer, Reinhard [VerfasserIn] |
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| | Ihrig, Petra [VerfasserIn] |
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| | Perry, David [VerfasserIn] |
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| | Orfanos, Constantin E [VerfasserIn] |
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| | Hannun, Yusuf A [VerfasserIn] |
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| Titel: | Bcl-2 antagonizes apoptotic cell death induced by two new ceramide analogues |
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| Verf.angabe: | Thomas Wieder, Christoph C. Geilen, Thomas Kolter, Farsaneh Sadeghlar, Konrad Sandhoff, Reinhard Brossmer, Petra Ihrig, David Perry, Constantin E. Orfanos, Yusuf A Hannun |
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| E-Jahr: | 1997 |
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| Jahr: | July 1997 |
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| Umfang: | 5 S. |
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| Fussnoten: | Elektronische Reproduktion der Druck-Ausgabe 14. Dezember 2000 ; Gesehen am 01.07.2024 |
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| Titel Quelle: | Enthalten in: Vereinigung der Europäischen Biochemischen GesellschaftenFEBS letters |
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| Ort Quelle: | Chichester : Wiley, 1968 |
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| Jahr Quelle: | 1997 |
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| Band/Heft Quelle: | 411(1997), 2, Seite 260-264 |
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| ISSN Quelle: | 1873-3468 |
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| Abstract: | Ceramides which arise in part from the breakdown of sphingomyelin comprise a class of antiproliferative lipids and have been implicated in the regulation of programmed cell death better known as apoptosis. In the present study, two new synthetic ceramide analogues, N-thioacetylsphingosine and FS-5, were used in Molt4 cells to induce cell death. Besides their cytotoxic effects at concentrations ≥14 μM the data obtained clearly show that both analogues induced apoptosis at concentrations below this critical concentration as assessed by trypan blue exclusion and cleavage of the death substrate poly-(ADP-ribose) polymerase (PARP). Additional experiments in bcl-2-transfected Molt4 cells revealed that the apoptotic but not the lytic effects of the analogues were antagonized by the apoptosis inhibitor Bcl-2. Furthermore, neither N-thio-acetylsphingosine nor FS-5 induced PARP cleavage in bcl-2-transfected Molt4 cells indicating that the induction of apoptotic cell death by cell permeable ceramides is not due to unspecific disturbance of the cell membrane. |
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| DOI: | doi:10.1016/S0014-5793(97)00717-5 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/S0014-5793(97)00717-5 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0014579397007175 |
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| | DOI: https://doi.org/10.1016/S0014-5793(97)00717-5 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Apoptosis |
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| | Bcl-2 |
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| | Sphingomyelin cycle |
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| | Synthetic ceramide |
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| K10plus-PPN: | 1892786346 |
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| Verknüpfungen: | → Zeitschrift |
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Bcl-2 antagonizes apoptotic cell death induced by two new ceramide analogues / Wieder, Thomas [VerfasserIn]; July 1997 (Online-Ressource)
