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| Verfasst von: | Jeong, Mingeum [VerfasserIn]  |
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| | Cortopassi, Francesco [VerfasserIn] |
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| | See, Jia-Xiang [VerfasserIn] |
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| | Torre, Carolina de la [VerfasserIn] |
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| | Cerwenka, Adelheid [VerfasserIn] |
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| | Stojanovic, Ana [VerfasserIn] |
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| Titel: | Vitamin A-treated natural killer cells reduce interferon-gamma production and support regulatory T-cell differentiation |
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| Verf.angabe: | Mingeum Jeong, Francesco Cortopassi, Jia-Xiang See, Carolina De La Torre, Adelheid Cerwenka and Ana Stojanovic |
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| E-Jahr: | 2024 |
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| Jahr: | 09 April 2024 |
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| Umfang: | 14 S. |
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| Illustrationen: | Diagramme |
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| Fussnoten: | Gesehen am 02.07.2024 |
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| Titel Quelle: | Enthalten in: European journal of immunology |
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| Ort Quelle: | Weinheim : Wiley-VCH, 1971 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 54(2024), 7, Artikel-ID e2250342 |
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| ISSN Quelle: | 1521-4141 |
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| Abstract: | Natural killer (NK) cells are innate cytotoxic lymphocytes that contribute to immune responses against stressed, transformed, or infected cells. NK cell effector functions are regulated by microenvironmental factors, including cytokines, metabolites, and nutrients. Vitamin A is an essential micronutrient that plays an indispensable role in embryogenesis and development, but was also reported to regulate immune responses. However, the role of vitamin A in regulating NK cell functions remains poorly understood. Here, we show that the most prevalent vitamin A metabolite, all-trans retinoic acid (atRA), induces transcriptional and functional changes in NK cells leading to altered metabolism and reduced IFN-γ production in response to a wide range of stimuli. atRA-exposed NK cells display a reduced ability to support dendritic cell (DC) maturation and to eliminate immature DCs. Moreover, they support the polarization and proliferation of regulatory T cells. These results imply that in vitamin A-enriched environments, NK cells can acquire functions that might promote tolerogenic immunity and/or immunosuppression. |
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| DOI: | doi:10.1002/eji.202250342 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1002/eji.202250342 |
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| | kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.202250342 |
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| | DOI: https://doi.org/10.1002/eji.202250342 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | all-trans retinoic acid |
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| | IFN-γ |
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| | NK cells |
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| | Regulatory T cells |
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| | Vitamin A |
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| K10plus-PPN: | 1893062716 |
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| Verknüpfungen: | → Zeitschrift |
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Vitamin A-treated natural killer cells reduce interferon-gamma production and support regulatory T-cell differentiation / Jeong, Mingeum [VerfasserIn]; 09 April 2024 (Online-Ressource)
