| Online-Ressource |
Verfasst von: | Mösch, Michèle [VerfasserIn]  |
| Usemann, Jakob [VerfasserIn]  |
| Bruder, Elisabeth [VerfasserIn]  |
| Romero, Philipp [VerfasserIn]  |
| Schwab, Constantin [VerfasserIn]  |
| Niesler, Beate [VerfasserIn]  |
| Tapia-Laliena, María Angeles [VerfasserIn]  |
| Khasanov, Rasul [VerfasserIn]  |
| Nisar, Tauseef [VerfasserIn]  |
| Holland-Cunz, Stefan [VerfasserIn]  |
| Keck, Simone [VerfasserIn]  |
Titel: | Associations of mucosal nerve fiber innervation density with Hirschsprung-associated enterocolitis |
Titelzusatz: | a retrospective three-center cohort study |
Verf.angabe: | Michèle Moesch, Jakob Usemann, Elisabeth Bruder, Philipp Romero, Constantin Schwab, Beate Niesler, Maria Angeles Tapia-Laliena, Rasul Khasanov, Tauseef Nisar, Study Group NIG Retro, Stefan Holland-Cunz, Simone Keck |
E-Jahr: | 2023 |
Jahr: | August 2023 |
Umfang: | 11 S. |
Fussnoten: | Artikel online veröffentlicht: 14. Oktober 2022 ; Gesehen am 09.07.2024 ; Verlagslink funktioniert nicht |
Titel Quelle: | Enthalten in: European journal of pediatric surgery |
Ort Quelle: | Stuttgart : Thieme, 1991 |
Jahr Quelle: | 2023 |
Band/Heft Quelle: | 33(2023), 4 vom: Aug., Seite 299-309 |
ISSN Quelle: | 1439-359X |
Abstract: | Objective Hirschsprung's disease (HSCR) is a congenital intestinal neurodevelopmental disorder characterized by the absence of enteric ganglion cells in the distal colon. Although Hirschsprung-associated enterocolitis (HAEC) is the most frequent life-threatening complication in HSCR, to date reliable biomarkers predicting the likelihood of HAEC are yet to be established. We established a three-center retrospective study including 104 HSCR patients surgically treated between 1998 and 2019. Materials and Methods Patient-derived cryopreserved or paraffin-preserved colonic tissue at surgery was analyzed via βIII-tubulin immunohistochemistry. We subsequently determined extrinsic mucosal nerve fiber density in resected rectosigmoid specimens and classified HSCR patients accordingly into nerve fiber-high or fiber-low groups. We compared the distribution of clinical parameters obtained from medical records between the fiber-high (n= 36) and fiber-low (n = 68) patient groups. We assessed the association between fiber phenotype and enterocolitis using univariate and multivariate logistic regression adjusted for age at operation. Results Enterocolitis was more prevalent in patients with sparse mucosal nerve fiber innervation (fiber-low phenotype, 87%) compared with the fiber-high phenotype (13%; p = 0.002). In addition, patients developing enterocolitis had a younger age at surgery (3 vs. 7 months; p = 0.016). In the univariate analysis, the odds for enterocolitis development in the fiber-low phenotype was 5.26 (95% confidence interval [CI], 1.67-16.59; p = 0.005) and 4.01 (95% CI, 1.22-13.17; p = 0.022) when adjusted for age. Conclusion Here, we showed that HSCR patients with a low mucosal nerve fiber innervation grade in the distal aganglionic colon have a higher risk of developing HAEC. Consequently, histopathologic analysis of the nerve fiber innervation grade could serve as a novel sensitive prognostic marker associated with the development of enterocolitis in HSCR patients. |
DOI: | doi:10.1055/a-1889-6355 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1055/a-1889-6355 |
| Volltext: https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1889-6355 |
| DOI: https://doi.org/10.1055/a-1889-6355 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1894704088 |
Verknüpfungen: | → Zeitschrift |
Associations of mucosal nerve fiber innervation density with Hirschsprung-associated enterocolitis / Mösch, Michèle [VerfasserIn]; August 2023 (Online-Ressource)