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Verfasst von:Mamilos, Andreas [VerfasserIn]   i
 Lein, Alexander [VerfasserIn]   i
 Winter, Lina [VerfasserIn]   i
 Haas, Markus [VerfasserIn]   i
 Reichert, Torsten E. [VerfasserIn]   i
 Ettl, Tobias [VerfasserIn]   i
 Künzel, Julian [VerfasserIn]   i
 Spanier, Gerrit [VerfasserIn]   i
 Brochhausen, Christoph [VerfasserIn]   i
Titel:Immunohistochemical assessment of microvessel density in OSCC
Titelzusatz:spatial heterogeneity of angiogenesis and its impact on survival
Verf.angabe:Andreas Mamilos, Alexander Lein, Lina Winter, Markus Haas, Torsten E. Reichert, Tobias Ettl, Julian Künzel, Gerrit Spanier and Christoph Brochhausen
E-Jahr:2023
Jahr:8 October 2023
Umfang:11 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 16.07.2024
Titel Quelle:Enthalten in: Biomedicines
Ort Quelle:Basel : MDPI, 2013
Jahr Quelle:2023
Band/Heft Quelle:11(2023), 10, Artikel-ID 2724, Seite 1-11
ISSN Quelle:2227-9059
Abstract:(1) Background Oral squamous cell carcinomas (OSCC) are a common malignancy of the oral cavity and are often diagnosed when they have already spread to the regional lymph nodes. Advanced stages of cancer are characterized by the development of distant metastases. Angiogenesis, a hallmark of cancer, is known to contribute to cancer progression and metastasis. High microvessel density (MVD) has been linked to poor clinical outcomes in various types of cancer. (2) Methods: In this study, we aimed to investigate the spatial heterogeneity of blood vessels by comparing the tumor center and invasion front and to evaluate its prognostic value in OSCC. A total of 71 OSCC patient specimens were collected. The tissue was immunohistochemically stained using CD31 antibody to assess the MVD in the tumor center and the invasion front. Furthermore, the associations between the histopathological parameters, including MVD, disease-free survival (DFS), and overall survival (OS) were computed. (3) Results: In our study, we found a significantly higher presence of blood vessels at the invasion front of OSCCs compared to the tumor center. However, we did not observe any significant differences in MVD between different tumor stages. High intratumoral MVD was shown to be a positive prognostic factor for DFS (p = 0.047). (4) Conclusions: To the best of our knowledge, we were the first to analyze MVD as a prognostic factor by considering its spatial heterogeneity in OSCC. However, further studies are warranted to further elucidate the complexity of microvascular spatial heterogeneity and its influence on prognosis.
DOI:doi:10.3390/biomedicines11102724
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.3390/biomedicines11102724
 kostenfrei: Volltext: https://www.mdpi.com/2227-9059/11/10/2724
 DOI: https://doi.org/10.3390/biomedicines11102724
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:angiogenesis
 immunohistochemistry
 microvessel density
 oral squamous cell carcinoma
 spatial heterogeneity
 survival
K10plus-PPN:1895489776
Verknüpfungen:→ Zeitschrift

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