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Verfasst von:Qian, Yuquan [VerfasserIn]   i
 Liu, Baojiang [VerfasserIn]   i
 Weiß, Christel [VerfasserIn]   i
 Zhu, Xu [VerfasserIn]   i
 Teufel, Andreas [VerfasserIn]   i
Titel:Distance matters: correlation of hepatocellular carcinoma nodule distance to overall survival
Titelzusatz:liver : research article
Verf.angabe:Yuquan Qian, Baojiang Liu, Christel Weiss, Xu Zhu, Andreas Teufel
E-Jahr:2023
Jahr:January 31 2023
Umfang:8 S.
Illustrationen:Illustrationen
Fussnoten:Online veröffentlicht: 16. Februar 2022 ; Gesehen am 16.07.2024
Titel Quelle:Enthalten in: Digestive diseases
Ort Quelle:Basel : Karger, 1983
Jahr Quelle:2023
Band/Heft Quelle:41(2023), 1, Seite 107-114
ISSN Quelle:1421-9875
Abstract:Introduction: Hepatocellular carcinoma (HCC) may occur with several simultaneous tumor foci in the liver (multifocal HCC). Molecular biology indicated that the larger the distance between two tumor nodules, the more those two nodules differed in their genetic composition. Therefore, we explored whether the overall survival (OS) of patients with HCC depends on the mutual distance of the HCC nodules. Methods: In a retrospective study of 92 patients, CT/MRI images and survival data of the patients were collected. Based on the CT or MRI images at the time of diagnosis, the size of each tumor, the distance between the centers (center distance), and adjacent edges (edge distance) of the tumor nodules were measured, respectively. These data, combined with the number of tumor nodules and clinical characteristics, were compared with the patient’s OS data. Results: As expected, the average tumor diameter was significantly associated with patient survival in univariate Cox regression analysis (p = 0.00028, hazard ratio [HR] = 1.2). However, in multivariate analysis, the average center distance (p = 0.036, HR = 1.18) and average edge distance (p = 0.033, HR = 0.84) were also significantly associated with survival. Conclusion: Thus, not only the size of multiple HCC lesions but also their distance is important for the prognosis of patients with HCC. This may be of particular interest in patients with two nodules and BCLC B and C stages for the selection of therapeutic modalities and/or procedures.
DOI:doi:10.1159/000522622
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1159/000522622
 Volltext: https://karger.com/ddi/article/41/1/107/841560/Distance-Matters-Correlation-of-Hepatocellular
 DOI: https://doi.org/10.1159/000522622
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1895498147
Verknüpfungen:→ Zeitschrift

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