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Status: Bibliographieeintrag

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Verfasst von:Sigle, August [VerfasserIn]   i
 Borkowetz, Angelika [VerfasserIn]   i
 Hardenberg, Jost von [VerfasserIn]   i
 Drerup, Martin [VerfasserIn]   i
 Kornienko, Kira [VerfasserIn]   i
 Kwe, Jeremy [VerfasserIn]   i
 Wenzel, Mike [VerfasserIn]   i
 Mandel, Philipp [VerfasserIn]   i
 Westhoff, Niklas Christian [VerfasserIn]   i
 Rieger, Constantin [VerfasserIn]   i
 Hoffmann, Manuela A. [VerfasserIn]   i
 Ortner, Gernot [VerfasserIn]   i
 Mahjoub, Samy [VerfasserIn]   i
Titel:Prediction of Significant Prostate Cancer in Equivocal Magnetic Resonance Imaging Lesions
Titelzusatz:A High-volume International Multicenter Study
Verf.angabe:August Sigle, Angelika Borkowetz, Jost von Hardenberg, Martin Drerup, Kira Kornienko, Jeremy Kwe, Mike Wenzel, Philipp Mandel, Niklas Westhoff, Constantin Rieger, Manuela A. Hoffmann, Gernot Ortner, Samy Mahjoub, GeSRU Academics Prostate Cancer Group
E-Jahr:2023
Jahr:July 2023
Umfang:8 S.
Illustrationen:Illustrationen
Fussnoten:Online verfügbar: 17. Februar 2023, Artikelversion: 26. Juli 2023 ; Gesehen am 17.07.2024
Titel Quelle:Enthalten in: European urology focus
Ort Quelle:Amsterdam : Elsevier, 2015
Jahr Quelle:2023
Band/Heft Quelle:9(2023), 4 vom: Juli, Seite 606-613
ISSN Quelle:2405-4569
Abstract:Background - Decision of performing prostate biopsy in men with Prostate Imaging Reporting and Data System (PI-RADS) 3 findings in prostate magnetic resonance imaging (MRI) is challenging as they have a low but still relevant risk of harboring significant prostate cancer (sPC). - Objective - To identify clinical predictors of sPC in men with PI-RADS 3 lesions in prostate MRI and to analyze the hypothetical effect of incorporating prostate-specific antigen density (PSAD) into biopsy decision. - Design, setting, and participants - We analyzed a retrospective multinational cohort from ten academic centers comprising 1476 men who underwent a combined prostate biopsy (MRI targeted plus systematic biopsy) between February 2012 and April 2021 due to a PI-RADS 3 lesion in prostate MRI. - Outcome measurements and statistical analysis - The primary outcome was the detection of sPC (ISUP ≥2) in a combined biopsy. Predictors were identified by a regression analysis. Descriptive statistics were applied to evaluate the hypothetical effect of involving PSAD into biopsy decision. - Results and limitations - Of all patients, 273/1476 (18.5%) were diagnosed with sPC. MRI-targeted biopsy diagnosed fewer sPC cases than combined strategy: 183/1476 (12.4%) versus 273/1476 (18.5%), p < 0.01. Age (odds ratio [OR] 1.10 [95% confidence interval {CI}: 1.05-1.15], p < 0.001), prior negative biopsy (OR 0.46 [0.24-0.89], p = 0.022), and PSAD (p < 0.001) were found to be independent predictors of sPC. Applying a PSAD cutoff of 0.15, 817/1398 (58.4%) biopsies would have been avoided at the cost of missing sPC in 91 (6.5%) men. Limitations were the retrospective design, heterogeneity of the study cohort due to the long inclusion period, and no central revision of MRI. - Conclusions - Age, previous biopsy status, and PSAD were found to be independent predictors of sPC in men with equivocal prostate MRI. Implementation of PSAD into biopsy decision can avoid unnecessary biopsies. Clinical parameters such as PSAD need validation in a prospective setting. - Patient summary - In this study, we looked for clinical predictors of significant prostate cancer in men with Prostate Imaging Reporting and Data System 3 lesions in prostate magnetic resonance imaging. We identified age, previous biopsy status, and especially prostate-specific antigen density as independent predictors.
DOI:doi:10.1016/j.euf.2023.01.020
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.euf.2023.01.020
 Volltext: https://www.sciencedirect.com/science/article/pii/S240545692300038X
 DOI: https://doi.org/10.1016/j.euf.2023.01.020
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Image-guided biopsy
 Magnetic resonance imaging
 Prostate Imaging Reporting and Data System
 Prostatic neoplasms
K10plus-PPN:1895630584
Verknüpfungen:→ Zeitschrift

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