Epidural versus subcutaneous administration of alfentanil for the management of postoperative pain

• Verfasst von: Chrubasik, Joachim [VerfasserIn]
• Verfasst von: Chrubasik, Sigrun [VerfasserIn]
• Verfasst von: Ren, Yungong [VerfasserIn]
• Verfasst von: Schulte Mönting, Jürgen [VerfasserIn]
• Verfasst von: Martin, Eike [VerfasserIn]
• Titel: Epidural versus subcutaneous administration of alfentanil for the management of postoperative pain
• Verf.angabe: Joachim Chrubasik, Sigrun Chrubasik, Yungong Ren, Jürgen Schulte-Mönting, Eike Martin
• E-Jahr: 1994
• Jahr: June 1994
• Umfang: 5 S.
• Fussnoten: Gesehen am 18.07.2024
• Titel Quelle: Enthalten in: Anesthesia & analgesia
• Ort Quelle: Baltimore, Md. : Williams & Wilkins, 1957
• Jahr Quelle: 1994
• Band/Heft Quelle: 78(1994), 6, Seite 1114-1118
• ISSN Quelle: 1526-7598
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1895732328

Abstract

This study was designed to compare the efficacy and serum concentrations of alfentanil given subcutaneously (SQ) or epidurally (EPID) for treatment of postoperative pain. Following abdominal surgery, patients (n = 12) were randomly assigned to receive double-blind SQ or EPID alfentanil over 24 h via the allocated route (1 mg along with 0.2 mg/h and 0.2-mg boluses on demand) and saline via the other route of administration using a patient-controlled analgesic (PCA) delivery system. Significantly less EPID alfentanil produced better quality analgesia and fewer side effects than SQ alfentanil. The fact that EPID analgesia was maintained with serum alfentanil concentrations less than those producing systemic analgesia confirms the spinal site of the EPID alfentanil action.