| Online-Ressource |
Verfasst von: | Lübke, Johannes [VerfasserIn]  |
| Naumann, Nicole [VerfasserIn]  |
| Hoffmann, Oliver [VerfasserIn]  |
| Horny, Hans-Peter [VerfasserIn]  |
| Sotlar, Karl [VerfasserIn]  |
| Rudelius, Martina [VerfasserIn]  |
| Metzgeroth, Georgia [VerfasserIn]  |
| Fabarius, Alice [VerfasserIn]  |
| Hofmann, Wolf-Karsten [VerfasserIn]  |
| Reiter, Andreas [VerfasserIn]  |
| Schwaab, Juliana [VerfasserIn]  |
Titel: | A clinical, morphological and molecular study of 70 patients with gastrointestinal involvement in systemic mastocytosis |
Verf.angabe: | Johannes Lübke, Nicole Naumann, Oliver Hoffmann, Hans-Peter Horny, Karl Sotlar, Martina Rudelius, Georgia Metzgeroth, Alice Fabarius, Wolf-Karsten Hofmann, Andreas Reiter & Juliana Schwaab |
E-Jahr: | 2024 |
Jahr: | 06 January 2024 |
Umfang: | 9 S. |
Illustrationen: | Illustrationen |
Fussnoten: | Gesehen am 19.07.2024 |
Titel Quelle: | Enthalten in: Scientific reports |
Ort Quelle: | [London] : Springer Nature, 2011 |
Jahr Quelle: | 2024 |
Band/Heft Quelle: | 14(2024), Artikel-ID 702, Seite 1-9 |
ISSN Quelle: | 2045-2322 |
Abstract: | In 70 patients with KIT D816V positive systemic mastocytosis (SM) including 36 patients with advanced SM (AdvSM), we correlated the extent of reported mucosal mast cell ([m]MC) infiltration of the upper and/or lower gastrointestinal tract (UGIT, n = 63; LGIT, n = 64; both, n = 57) with symptoms and markers of MC burden/subtype. GI symptoms were reported by all patients (mean 2.1 number of symptoms). A strong mMC infiltration was identified in 24 patients (UGIT, 17/63, 27%; LGIT, 19/64, 30%). Concurrent involvement of UGIT and LGIT (n = 12) correlated with female gender (75%) and a higher symptom burden (mean 2.7) but not with MC burden or subtype. Significant differences between non-AdvSM and AdvSM were reported regarding food intolerance (54% vs. 17%), cramping (54% vs. 22%) and weight loss (0% vs. 64%). KIT D816V was identified in 54/56 (96%) available biopsies. In 46 patients, digital PCR revealed a correlation with low albumin levels (r = − 0.270, P = 0.069) and the KIT D816V VAF in peripheral blood (r = 0.317, P = 0.036) but not with the extent of mMC infiltration or markers of MC burden/subtype. Although MC mediator triggered GI symptoms have a substantial impact on the quality of life, correlation to objective disease parameters is lacking thus making its systematic assessment challenging. |
DOI: | doi:10.1038/s41598-023-49749-z |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41598-023-49749-z |
| kostenfrei: Volltext: https://www.nature.com/articles/s41598-023-49749-z |
| DOI: https://doi.org/10.1038/s41598-023-49749-z |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Gastrointestinal diseases |
| Myeloproliferative disease |
K10plus-PPN: | 1895955157 |
Verknüpfungen: | → Zeitschrift |
¬A¬ clinical, morphological and molecular study of 70 patients with gastrointestinal involvement in systemic mastocytosis / Lübke, Johannes [VerfasserIn]; 06 January 2024 (Online-Ressource)