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| Verfasst von: | Juni, Rio P. [VerfasserIn]  |
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| | Kocken, Jordy M. M. [VerfasserIn] |
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| | Abreu, Ricardo C. [VerfasserIn] |
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| | Ottaviani, Lara [VerfasserIn] |
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| | Davalan, Tim [VerfasserIn] |
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| | Duygu, Burcu [VerfasserIn] |
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| | Poels, Ella M. [VerfasserIn] |
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| | Vasilevich, Aliaksei [VerfasserIn] |
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| | Hegenbarth, Jana C. [VerfasserIn] |
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| | Appari, Mahesh [VerfasserIn] |
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| | Bitsch, Nicole [VerfasserIn] |
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| | Olieslagers, Serve [VerfasserIn] |
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| | Schrijvers, Dorien M. [VerfasserIn] |
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| | Stoll, Monika [VerfasserIn] |
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| | Heineke, Jörg [VerfasserIn] |
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| | de Boer, Jan [VerfasserIn] |
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| | de Windt, Leon J. [VerfasserIn] |
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| | da Costa Martins, Paula A. [VerfasserIn] |
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| Titel: | MicroRNA-216a is essential for cardiac angiogenesis |
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| Verf.angabe: | Rio P. Juni, Jordy M.M. Kocken, Ricardo C. Abreu, Lara Ottaviani, Tim Davalan, Burcu Duygu, Ella M. Poels, Aliaksei Vasilevich, Jana C. Hegenbarth, Mahesh Appari, Nicole Bitsch, Serve Olieslagers, Dorien M. Schrijvers, Monika Stoll, Joerg Heineke, Jan de Boer, Leon J. de Windt and Paula A. da Costa Martins |
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| E-Jahr: | 2023 |
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| Jahr: | 7 June 2023 |
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| Umfang: | 22 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 17. April 2023, Artikelversion: 7. Juni 2023 ; Gesehen am 22.07.2024 |
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| Titel Quelle: | Enthalten in: Molecular therapy |
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| Ort Quelle: | Amsterdam : Elsevier, 2000 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 31(2023), 6, Seite 1807-1828 |
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| ISSN Quelle: | 1525-0024 |
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| Abstract: | While it is experimentally supported that impaired myocardial vascularization contributes to a mismatch between myocardial oxygen demand and supply, a mechanistic basis for disruption of coordinated tissue growth and angiogenesis in heart failure remains poorly understood. Silencing strategies that impair microRNA biogenesis have firmly implicated microRNAs in the regulation of angiogenesis, and individual microRNAs prove to be crucial in developmental or tumor angiogenesis. A high-throughput functional screening for the analysis of a whole-genome microRNA silencing library with regard to their phenotypic effect on endothelial cell proliferation as a key parameter, revealed several anti- and pro-proliferative microRNAs. Among those was miR-216a, a pro-angiogenic microRNA which is enriched in cardiac microvascular endothelial cells and reduced in expression under cardiac stress conditions. miR-216a null mice display dramatic cardiac phenotypes related to impaired myocardial vascularization and unbalanced autophagy and inflammation, supporting a model where microRNA regulation of microvascularization impacts the cardiac response to stress. |
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| DOI: | doi:10.1016/j.ymthe.2023.04.007 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.ymthe.2023.04.007 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1525001623002058 |
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| | DOI: https://doi.org/10.1016/j.ymthe.2023.04.007 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | angiogenesis |
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| | autophagy |
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| | cardiac remodeling |
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| | endothelial cells |
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| | heart failure |
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| | microRNAs |
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| K10plus-PPN: | 1896000614 |
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| Verknüpfungen: | → Zeitschrift |
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MicroRNA-216a is essential for cardiac angiogenesis / Juni, Rio P. [VerfasserIn]; 7 June 2023 (Online-Ressource)
