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Verfasst von:Manoharan, Renuka Ramalingam [VerfasserIn]   i
 Prasad, Ankush [VerfasserIn]   i
 Pospíšil, Pavel [VerfasserIn]   i
 Kzhyshkowska, Julia [VerfasserIn]   i
Titel:ROS signaling in innate immunity via oxidative protein modifications
Verf.angabe:Renuka Ramalingam Manoharan, Ankush Prasad, Pavel Pospíšil and Julia Kzhyshkowska
E-Jahr:2024
Jahr:07 March 2024
Umfang:15 S.
Fussnoten:Gesehen am 25.07.2024
Titel Quelle:Enthalten in: Frontiers in immunology
Ort Quelle:Lausanne : Frontiers Media, 2010
Jahr Quelle:2024
Band/Heft Quelle:15(2024), Artikel-ID 1359600, Seite 1-15
ISSN Quelle:1664-3224
Abstract:The innate immune response represents the first-line of defense against invading pathogens. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have been implicated in various aspects of innate immune function, which involves respiratory bursts and inflammasome activation. These reactive species widely distributed within the cellular environment are short-lived intermediates that play a vital role in cellular signaling and proliferation and are likely to depend on their subcellular site of formation. NADPH oxidase complex of phagocytes is known to generate superoxide anion radical (O2•−) that functions as a precursor for antimicrobial hydrogen peroxide (H2O2) production, and H2O2 is utilized by myeloperoxidase (MPO) to generate hypochlorous acid (HOCl) that mediates pathogen killing. H2O2 modulates the expression of redox-responsive transcriptional factors, namely NF-kB, NRF2, and HIF-1, thereby mediating redox-based epigenetic modification. Survival and function of immune cells are under redox control and depend on intracellular and extracellular levels of ROS/RNS. The current review focuses on redox factors involved in the activation of immune response and the role of ROS in oxidative modification of proteins in macrophage polarization and neutrophil function.
DOI:doi:10.3389/fimmu.2024.1359600
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.3389/fimmu.2024.1359600
 kostenfrei: Volltext: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1359600/full
 DOI: https://doi.org/10.3389/fimmu.2024.1359600
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Inflammation
 innate immune response
 macrophage
 Neutrophils
 Oxidative Stress
 protein oxidation
 Reactive Oxygen Species
K10plus-PPN:1896415032
Verknüpfungen:→ Zeitschrift

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