Status: Bibliographieeintrag
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| Verfasst von: | Cola, Reto [VerfasserIn]  |
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| | Roccaro-Waldmeyer, Diana M. [VerfasserIn] |
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| | Naim, Samara [VerfasserIn] |
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| | Babalian, Alexandre [VerfasserIn] |
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| | Seebeck, Petra [VerfasserIn] |
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| | Alvarez-Bolado, Gonzalo [VerfasserIn] |
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| | Celio, Marco R. [VerfasserIn] |
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| Titel: | Chemo- and optogenetic activation of hypothalamic Foxb1-expressing neurons and their terminal endings in the rostral-dorsolateral PAG leads to tachypnea, bradycardia, and immobility |
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| Verf.angabe: | Reto B. Cola, Diana M. Roccaro-Waldmeyer, Samara Naim, Alexandre Babalian, Petra Seebeck, Gonzalo Alvarez-Bolado, Marco R. Celio |
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| E-Jahr: | 2024 |
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| Jahr: | 01 February, 2024 |
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| Umfang: | 26 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 25.07.2024 |
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| Titel Quelle: | Enthalten in: eLife |
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| Ort Quelle: | Cambridge : eLife Sciences Publications, 2012 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 12(2024) vom: Feb., Artikel-ID RP86737, Seite 1-26 |
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| ISSN Quelle: | 2050-084X |
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| Abstract: | Foxb1 -expressing neurons occur in the dorsal premammillary nucleus (PMd) and further rostrally in the parvafox nucleus, a longitudinal cluster of neurons in the lateral hypothalamus of rodents. The descending projection of these Foxb1+ neurons end in the dorsolateral part of the periaqueductal gray (dlPAG). The functional role of the Foxb1+ neuronal subpopulation in the PMd and the parvafox nucleus remains elusive. In this study, the activity of the Foxb1+ neurons and of their terminal endings in the dlPAG in mice was selectively altered by employing chemo- and optogenetic tools. Our results show that in whole-body barometric plethysmography, hM3Dq-mediated, global Foxb1+ neuron excitation activates respiration. Time-resolved optogenetic gain-of-function manipulation of the terminal endings of Foxb1+ neurons in the rostral third of the dlPAG leads to abrupt immobility and bradycardia. Chemogenetic activation of Foxb1+ cell bodies and ChR2-mediated excitation of their axonal endings in the dlPAG led to a phenotypical presentation congruent with a 'freezing-like' situation during innate defensive behavior. |
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| DOI: | doi:10.7554/eLife.86737 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.7554/eLife.86737 |
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| | DOI: https://doi.org/10.7554/eLife.86737 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | Bradycardia |
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| | defensive behavior |
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| | dorsal premammillary nucleus |
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| | Forkhead Transcription Factors |
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| | Hypothalamus |
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| | immobility |
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| | Mice |
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| | mouse |
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| | Neurons |
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| | neuroscience |
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| | Optogenetics |
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| | parvafox nucleus |
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| | periaqueductal gray |
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| | respiration |
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| | Tachypnea |
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| K10plus-PPN: | 1896431224 |
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| Verknüpfungen: | → Zeitschrift |
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Chemo- and optogenetic activation of hypothalamic Foxb1-expressing neurons and their terminal endings in the rostral-dorsolateral PAG leads to tachypnea, bradycardia, and immobility / Cola, Reto [VerfasserIn]; 01 February, 2024 (Online-Ressource)
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