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Status: Bibliographieeintrag

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Verfasst von:Metzner, Margareta [VerfasserIn]   i
 Zhevachevska, Daria [VerfasserIn]   i
 Schlechter, Annika [VerfasserIn]   i
 Kehrein, Florian [VerfasserIn]   i
 Schlecker, Julian [VerfasserIn]   i
 Murillo, Carlos [VerfasserIn]   i
 Brons, Stephan [VerfasserIn]   i
 Jäkel, Oliver [VerfasserIn]   i
 Martišíková, Mária [VerfasserIn]   i
 Gehrke, Tim [VerfasserIn]   i
Titel:Energy painting
Titelzusatz:helium-beam radiography with thin detectors and multiple beam energies
Verf.angabe:Margareta Metzner, Daria Zhevachevska, Annika Schlechter, Florian Kehrein, Julian Schlecker, Carlos Murillo, Stephan Brons, Oliver Jäkel, Mária Martišíková, Tim Gehrke
E-Jahr:2024
Jahr:19 February 2024
Umfang:19 S.
Fussnoten:Gesehen am 25.07.2024
Titel Quelle:Enthalten in: Physics in medicine and biology
Ort Quelle:Bristol : IOP Publ., 1956
Jahr Quelle:2024
Band/Heft Quelle:69(2024), 5, Seite 1-19
ISSN Quelle:1361-6560
Abstract:Objective.Compact ion imaging systems based on thin detectors are a promising prospect for the clinical environment since they are easily integrated into the clinical workflow. Their measurement principle is based on energy deposition instead of the conventionally measured residual energy or range. Therefore, thin detectors are limited in the water-equivalent thickness range they can image with high precision. This article presents ourenergy paintingmethod, which has been developed to render high precision imaging with thin detectors feasible even for objects with larger, clinically relevant water-equivalent thickness (WET) ranges.Approach.A detection system exclusively based on pixelated silicon Timepix detectors was used at the Heidelberg ion-beam therapy center to track single helium ions and measure their energy deposition behind the imaged object. Calibration curves were established for five initial beam energies to relate the measured energy deposition to WET. They were evaluated regarding their accuracy, precision and temporal stability. Furthermore, a 60 mm × 12 mm region of a wedge phantom was imaged quantitatively exploiting the calibrated energies and five different mono-energetic images. These mono-energetic images were combined in a pixel-by-pixel manner by averaging the WET-data weighted according to their single-ion WET precision (SIWP) and the number of contributing ions.Main result.A quantitative helium-beam radiograph of the wedge phantom with an average SIWP of 1.82(5) % over the entire WET interval from 150 mm to 220 mm was obtained. Compared to the previously used methodology, the SIWP improved by a factor of 2.49 ± 0.16. The relative stopping power value of the wedge derived from the energy-painted image matches the result from range pullback measurements with a relative deviation of only 0.4 %.Significance.The proposed method overcomes the insufficient precision for wide WET ranges when employing detection systems with thin detectors. Applying this method is an important prerequisite for imaging of patients. Hence, it advances detection systems based on energy deposition measurements towards clinical implementation.
DOI:doi:10.1088/1361-6560/ad247e
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1088/1361-6560/ad247e
 DOI: https://doi.org/10.1088/1361-6560/ad247e
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Helium
 Humans
 ion imaging
 ion-beam radiography
 ion-beam radiotherapy
 Ions
 Phantoms, Imaging
 proton therapy
 Radiography
 relative stopping power
 silicon pixel detectors
 Timepix
 Water
K10plus-PPN:1896448224
Verknüpfungen:→ Zeitschrift

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