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| Verfasst von: | Farahani, Ensieh [VerfasserIn]  |
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| | Reinert, Line S. [VerfasserIn] |
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| | Narita, Ryo [VerfasserIn] |
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| | Serrero, Manutea C. [VerfasserIn] |
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| | Skouboe, Morten Kelder [VerfasserIn] |
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| | van der Horst, Demi [VerfasserIn] |
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| | Assil, Sonia [VerfasserIn] |
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| | Zhang, Baocun [VerfasserIn] |
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| | Iversen, Marie B. [VerfasserIn] |
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| | Gutierrez, Eugenio [VerfasserIn] |
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| | Hazrati, Hossein [VerfasserIn] |
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| | Johannsen, Mogens [VerfasserIn] |
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| | Olagnier, David [VerfasserIn] |
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| | Kunze, Reiner [VerfasserIn] |
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| | Denham, Mark [VerfasserIn] |
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| | Mogensen, Trine H. [VerfasserIn] |
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| | Lappe, Michael [VerfasserIn] |
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| | Paludan, Søren R. [VerfasserIn] |
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| Titel: | The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation |
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| Verf.angabe: | Ensieh Farahani, Line S. Reinert, Ryo Narita, Manutea C. Serrero, Morten Kelder Skouboe, Demi van der Horst, Sonia Assil, Baocun Zhang, Marie B. Iversen, Eugenio Gutierrez, Hossein Hazrati, Mogens Johannsen, David Olagnier, Reiner Kunze, Mark Denham, Trine H. Mogensen, Michael Lappe, and Søren R. Paludan |
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| E-Jahr: | 2024 |
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| Jahr: | 27 February 2024 |
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| Umfang: | 27 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 15. Februar 2024 ; Gesehen am 29.07.2024 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 43(2024), 2 vom: Feb., Artikel-ID 113792, Seite 1-27 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Pattern recognition receptors (PRRs) induce host defense but can also induce exacerbated inflammatory responses. This raises the question of whether other mechanisms are also involved in early host defense. Using transcriptome analysis of disrupted transcripts in herpes simplex virus (HSV)-infected cells, we find that HSV infection disrupts the hypoxia-inducible factor (HIF) transcription network in neurons and epithelial cells. Importantly, HIF activation leads to control of HSV replication. Mechanistically, HIF activation induces autophagy, which is essential for antiviral activity. HSV-2 infection in vivo leads to hypoxia in CNS neurons, and mice with neuron-specific HIF1/2α deficiency exhibit elevated viral load and augmented PRR signaling and inflammatory gene expression in the CNS after HSV-2 infection. Data from human stem cell-derived neuron and microglia cultures show that HIF also exerts antiviral and inflammation-restricting activity in human CNS cells. Collectively, the HIF transcription factor system senses virus-induced hypoxic stress to induce cell-intrinsic antiviral responses and limit inflammation. |
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| DOI: | doi:10.1016/j.celrep.2024.113792 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.celrep.2024.113792 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S2211124724001207 |
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| | DOI: https://doi.org/10.1016/j.celrep.2024.113792 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | herpes simplex virus |
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| | HIF |
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| | immune evasion |
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| | immune regulation |
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| | innate antiviral defense |
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| | neurons |
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| K10plus-PPN: | 1896755801 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation / Farahani, Ensieh [VerfasserIn]; 27 February 2024 (Online-Ressource)
