Status: Bibliographieeintrag
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| Verfasst von: | Granados, Karol [VerfasserIn]  |
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| | Poelchen, Juliane [VerfasserIn] |
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| | Novak, Daniel [VerfasserIn] |
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| | Utikal, Jochen [VerfasserIn] |
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| Titel: | Cellular reprogramming |
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| Titelzusatz: | a model for melanoma cellular plasticity |
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| Verf.angabe: | Karol Granados, Juliane Poelchen, Daniel Novak and Jochen Utikal |
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| E-Jahr: | 2020 |
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| Jahr: | 5 November 2020 |
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| Umfang: | 14 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 29.07.2024 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 21(2020), 21 vom: Nov., Artikel-ID 8274, Seite 1-14 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | Cellular plasticity of cancer cells is often associated with phenotypic heterogeneity and drug resistance and thus remains a major challenge for the treatment of melanoma and other types of cancer. Melanoma cells have the capacity to switch their phenotype during tumor progression, from a proliferative and differentiated phenotype to a more invasive and dedifferentiated phenotype. However, the molecular mechanisms driving this phenotype switch are not yet fully understood. Considering that cellular heterogeneity within the tumor contributes to the high plasticity typically observed in melanoma, it is crucial to generate suitable models to investigate this phenomenon in detail. Here, we discuss the use of complete and partial reprogramming into induced pluripotent cancer (iPC) cells as a tool to obtain new insights into melanoma cellular plasticity. We consider this a relevant topic due to the high plasticity of melanoma cells and its association with a strong resistance to standard anticancer treatments. |
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| DOI: | doi:10.3390/ijms21218274 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/ijms21218274 |
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| | kostenfrei: Volltext: https://www.mdpi.com/1422-0067/21/21/8274 |
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| | DOI: https://doi.org/10.3390/ijms21218274 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cellular plasticity |
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| | heterogeneity |
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| | melanoma |
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| | partial reprogramming |
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| | phenotype switch |
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| K10plus-PPN: | 1896846033 |
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| Verknüpfungen: | → Zeitschrift |
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Cellular reprogramming / Granados, Karol [VerfasserIn]; 5 November 2020 (Online-Ressource)
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