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| Verfasst von: | Vasilescu, Andrei-Nicolae [VerfasserIn]  |
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| | Pfeiffer, Natascha [VerfasserIn] |
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| | Terraneo, Federica [VerfasserIn] |
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| | Riva, Marco Andrea [VerfasserIn] |
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| | Lang, Undine E [VerfasserIn] |
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| | Inta, Dragos [VerfasserIn] |
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| | Gass, Peter [VerfasserIn] |
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| Titel: | Region-specific rnhancement of c-fos expression by combined treatment with NMDA receptor agonists and antagonists with antidepressant potential |
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| Titelzusatz: | brief report |
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| Verf.angabe: | Andrei-Nicolae Vasilescu, Natascha Pfeiffer, Federica Terraneo, Marco Andrea Riva, Undine E. Lang, Dragos Inta, Peter Gass |
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| E-Jahr: | 2022 |
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| Jahr: | November 2022 |
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| Umfang: | 5 S. |
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| Fussnoten: | Artikel veröffentlicht: 17. August 2022 ; Gesehen am 30.07.2024 |
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| Titel Quelle: | Enthalten in: The international journal of neuropsychopharmacology |
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| Ort Quelle: | Oxford : Oxford Univ. Press, 1998 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 25(2022), 11 vom: Nov., Seite 946-950 |
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| ISSN Quelle: | 1469-5111 |
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| Abstract: | Rapastinel, formerly Glyx-13, is a novel positive allosteric modulator of the N-methyl-D-aspartate-receptor (NMDAR) that counteracts psychotomimetic actions of NMDAR antagonists. We set out to evaluate the effect of rapastinel alone or in combination with the global and GluN2B subunit-specific NMDAR antagonists MK-801 and Ro25-6981, respectively, on neuronal activation in relevant regions using c-fos brain mapping. Whereas rapastinel alone did not trigger significant c-fos expression beyond the prelimbic cortex, it strongly increased the c-fos expression induced by MK-801 in hippocampal, cingulate, and retrosplenial areas. Similar results were obtained when rapastinel was replaced by D-cycloserine. Our results reveal new interactions at network level between NMDAR modulators with possible implications regarding their therapeutic effects. |
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| DOI: | doi:10.1093/ijnp/pyac051 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1093/ijnp/pyac051 |
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| | Volltext: https://academic.oup.com/ijnp/article/25/11/946/6668855?login=true |
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| | DOI: https://doi.org/10.1093/ijnp/pyac051 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1896927106 |
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| Verknüpfungen: | → Zeitschrift |
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Region-specific rnhancement of c-fos expression by combined treatment with NMDA receptor agonists and antagonists with antidepressant potential / Vasilescu, Andrei-Nicolae [VerfasserIn]; November 2022 (Online-Ressource)
