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Status: Bibliographieeintrag

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Verfasst von:Anliker-Ort, Marion [VerfasserIn]   i
 Rodieux, Frédérique [VerfasserIn]   i
 Ziesenitz, Victoria C. [VerfasserIn]   i
 Atkinson, Andrew [VerfasserIn]   i
 Bielicki, Julia A. [VerfasserIn]   i
 Erb, Thomas O. [VerfasserIn]   i
 Gürtler, Nicolas [VerfasserIn]   i
 Holland-Cunz, Stefan [VerfasserIn]   i
 Duthaler, Urs [VerfasserIn]   i
 Rudin, Deborah [VerfasserIn]   i
 Haschke, Manuel [VerfasserIn]   i
 van den Anker, John [VerfasserIn]   i
 Pfister, Marc [VerfasserIn]   i
 Gotta, Verena [VerfasserIn]   i
Titel:Pharmacokinetics-based pediatric dose evaluation and optimization using saliva - a case study
Verf.angabe:Marion Anliker-Ort, PhD, Frédérique Rodieux, MD, Victoria C. Ziesenitz, MD, Andrew Atkinson, PhD, Julia A. Bielicki, MD, PhD, Thomas O. Erb, MD, Nicolas Gürtler, MD, Stefan Holland-Cunz, MD, Urs Duthaler, PhD, Deborah Rudin, PhD, Manuel Haschke, MD, John van den Anker, MD, PhD, FAAP, FCP, Marc Pfister, MD, PhD, FCP, and Verena Gotta, PhD
E-Jahr:2024
Jahr:July 2024
Umfang:10 S.
Illustrationen:Illustrationen
Fussnoten:Veröffentlicht: 18. März 2024 ; Gesehen am 01.08.2024
Titel Quelle:Enthalten in: Journal of clinical pharmacology
Ort Quelle:Hoboken, NJ : Wiley, 1961
Jahr Quelle:2024
Band/Heft Quelle:64(2024), 7, Seite 810-819
ISSN Quelle:1552-4604
Abstract:Understanding pharmacokinetics (PK) in children is a prerequisite to determine optimal pediatric dosing. As plasma sampling in children is challenging, alternative PK sampling strategies are needed. In this case study we evaluated the suitability of saliva as alternative PK matrix to simplify studies in infants, investigating metamizole, an analgesic used off-label in infants. Six plasma and 6 saliva PK sample collections were scheduled after a single intravenous dose of 10 mg/kg metamizole. Plasma/saliva pharmacometric (PMX) modeling of the active metabolites 4-methylaminoantipyrine (4-MAA) and 4-aminoantipyrine (4-AA) was performed. Various reduced plasma sampling scenarios were evaluated by PMX simulations. Saliva and plasma samples from 25 children were included (age range, 5-70 months; weight range, 8.7-24.8 kg). Distribution of metamizole metabolites between plasma and saliva was without delay. Estimated mean (individual range) saliva/plasma fractions of 4-MAA and 4-AA were 0.32 (0.05-0.57) and 0.57 (0.25-0.70), respectively. Residual variability of 4-MAA (4-AA) in saliva was 47% (28%) versus 17% (11%) in plasma. A simplified sampling scenario with up to 6 saliva samples combined with 1 plasma sample was associated with similar PK parameter estimates as the full plasma sampling scenario. This case study with metamizole shows increased PK variability in saliva compared to plasma, compromising its suitability as single matrix for PK studies in infants. Nonetheless, rich saliva sampling can reduce the number of plasma samples required for PK characterization, thereby facilitating the conduct of PK studies to optimize dosing in pediatric patients.
DOI:doi:10.1002/jcph.2428
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1002/jcph.2428
 kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jcph.2428
 DOI: https://doi.org/10.1002/jcph.2428
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:children
 infants
 metamizole
 pharmacokinetics
 pharmacometrics
 saliva
K10plus-PPN:1897331118
Verknüpfungen:→ Zeitschrift

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