| Online-Ressource |
Verfasst von: | Martel, Richard [VerfasserIn]  |
| Papafragou, Georgios [VerfasserIn]  |
| Weigand, Sylvia [VerfasserIn]  |
| Rolke, Roman [VerfasserIn]  |
| Prawitt, Dirk [VerfasserIn]  |
| Birklein, Frank [VerfasserIn]  |
| Treede, Rolf-Detlef [VerfasserIn]  |
| Magerl, Walter [VerfasserIn]  |
Titel: | Interindividual variability in cold-pressor pain sensitivity is not explained by peripheral vascular responding and generalizes to a C-nociceptor-specific pain phenotype |
Verf.angabe: | Richard D. Martel, Georgios Papafragou, Sylvia Weigand, Roman Rolke, Dirk Prawitt, Frank Birklein, Rolf-Detlef Treede, Walter Magerl |
E-Jahr: | 2024 |
Jahr: | March 2024 |
Umfang: | 14 S. |
Illustrationen: | Illustrationen |
Fussnoten: | Gesehen am 01.08.2024 |
Titel Quelle: | Enthalten in: Pain |
Ort Quelle: | New York, NY [u.a.] : Lippincott Williams and Wilkins, 1975 |
Jahr Quelle: | 2024 |
Band/Heft Quelle: | 165(2024), 3 vom: März, Seite e1-e14 |
ISSN Quelle: | 1872-6623 |
Abstract: | Pain sensitivity of healthy subjects in the cold-pressor (CP) test was proposed to be dichotomously distributed and to represent a pain sensitivity trait. Still, it has not been systematically explored which factors influence this pain sensitivity readout. The aim of this study was to distinguish potential contributions of local tissue-related factors such as perfusion and thermoregulation or gain settings in nociceptive systems. Cold-pressor-sensitive and CP-insensitive students screened from a medical student laboratory course were recruited for a CP retest with additional cardiovascular and bilateral local vascular monitoring. In addition, comprehensive quantitative sensory testing according to Deutscher Forschungsverbund Neuropathischer Schmerz standards and a sustained pinch test were performed. Cold pressor was reproducible across sessions (Cohen kappa 0.61 ± 0.14, P < 0.005). At 30 seconds in ice water, CP-sensitive subjects exhibited not only more pain (78.6 ± 26.3 vs 29.5 ± 17.5, P < 0.0001) but also significantly stronger increases in mean arterial blood pressure (12.6 ± 9.3 vs 5.6 ± 8.1 mm Hg, P < 0.05) and heart rate (15.0 ± 8.2 vs 7.1 ± 6.2 bpm, P < 0.005), and lower baroreflex sensitivity, but not local or vasoconstrictor reflex-mediated microcirculatory responses. Cold-pressor-sensitive subjects exhibited significantly lower pain thresholds also for cold, heat, and blunt pressure, and enhanced pain summation, but no significant differences in Aδ-nociceptor-mediated punctate mechanical pain. In conclusion, differences in nociceptive signal processing drove systemic cardiovascular responses. Baroreceptor activation suppressed pain and cardiovascular responses more efficiently in CP-insensitive subjects. Cold-pressor sensitivity generalized to a pain trait of C-fiber-mediated nociceptive channels, which was independent of local thermal and vascular changes in the ice-water-exposed hand. Thus, the C-fiber pain trait reflects gain setting of the nociceptive system. |
DOI: | doi:10.1097/j.pain.0000000000003049 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1097/j.pain.0000000000003049 |
| Volltext: https://journals.lww.com/pain/fulltext/2024/03000/interindividual_variability_in_cold_pressor_pain.15.aspx |
| DOI: https://doi.org/10.1097/j.pain.0000000000003049 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1897340796 |
Verknüpfungen: | → Zeitschrift |
Interindividual variability in cold-pressor pain sensitivity is not explained by peripheral vascular responding and generalizes to a C-nociceptor-specific pain phenotype / Martel, Richard [VerfasserIn]; March 2024 (Online-Ressource)