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Verfasst von:Mettmann, Vanessa [VerfasserIn]   i
 Baumhoer, Daniel [VerfasserIn]   i
 Bielack, Stefan S. [VerfasserIn]   i
 Blattmann, Claudia [VerfasserIn]   i
 Friedel, Godehard [VerfasserIn]   i
 von Kalle, Thekla [VerfasserIn]   i
 Kager, Leo [VerfasserIn]   i
 Kevric, Matthias [VerfasserIn]   i
 Nathrath, Michaela [VerfasserIn]   i
 Sorg, Benjamin [VerfasserIn]   i
 Dürken, Matthias [VerfasserIn]   i
 Hecker-Nolting, Stefanie [VerfasserIn]   i
Titel:Solitary pulmonary metastases at first recurrence of osteosarcoma
Titelzusatz:presentation, treatment, and survival of 219 patients of the Cooperative Osteosarcoma Study Group
Verf.angabe:Vanessa L. Mettmann, Daniel Baumhoer, Stefan S. Bielack, Claudia Blattmann, Godehard Friedel, Thekla von Kalle, Leo Kager, Matthias Kevric, Michaela Nathrath, Benjamin Sorg, Matthias Dürken, Stefanie Hecker-Nolting
E-Jahr:2023
Jahr:September 2023
Umfang:16 S.
Illustrationen:Illustrationen
Fussnoten:Online veröffentlicht: 7. August 2023 ; Gesehen am 01.08.2024
Titel Quelle:Enthalten in: Cancer medicine
Ort Quelle:Hoboken, NJ : Wiley, 2012
Jahr Quelle:2023
Band/Heft Quelle:12(2023), 17 vom: Sept., Seite 18219-18234
ISSN Quelle:2045-7634
Abstract:Background To evaluate patient and tumour characteristics, treatment and their impact on survival in patients with a solitary pulmonary metastasis at first relapse of high-grade osteosarcoma. Procedure Two-hundred and nineteen consecutive patients who had achieved a complete surgical remission and then developed a solitary pulmonary metastasis at first recurrence of high-grade osteosarcoma were retrospectively reviewed. Results Two hundred and three (94.9%) of 214 patients achieved a second complete remission. After a median time from initial diagnosis of osteosarcoma to first relapse of 2.3 years (range, 0.3-18.8 years), actuarial post-relapse overall survival after 2 and 5 years was 72.0% and 51.2%. Post-relapse event-free survival was 39.1% and 31.1%. Median follow-up time was 3.2 years (range, 0.1-29.4 years). A longer time until first relapse and diagnosis due to imaging were positive prognostic factors in uni- and multivariate analyses, as were a second complete surgical remission and, in regard to death, the absence of a subsequent relapse. The use of salvage chemotherapy and radiotherapy were not associated with patient outcomes, nor was the surgical approach (thoracoscopy vs. thoracotomy) nor the exploration (uni- vs. bilateral). Conclusion Approximately half of the patients who experience a solitary pulmonary relapse at first recurrence of osteosarcoma remain alive 5 years after this first relapse. Only one third will remain disease-free. A complete surgical resection of the lesion is essential for long-term survival while relapse chemotherapy does not seem to improve survival. Innovative therapies are required to improve outcomes.
DOI:doi:10.1002/cam4.6409
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1002/cam4.6409
 kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.6409
 DOI: https://doi.org/10.1002/cam4.6409
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:osteosarcoma
 pulmonary metastases
 recurrence
 survival
K10plus-PPN:1897355319
Verknüpfungen:→ Zeitschrift

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