| Online-Ressource |
Verfasst von: | Mettmann, Vanessa [VerfasserIn]  |
| Baumhoer, Daniel [VerfasserIn]  |
| Bielack, Stefan S. [VerfasserIn]  |
| Blattmann, Claudia [VerfasserIn]  |
| Friedel, Godehard [VerfasserIn]  |
| von Kalle, Thekla [VerfasserIn]  |
| Kager, Leo [VerfasserIn]  |
| Kevric, Matthias [VerfasserIn]  |
| Nathrath, Michaela [VerfasserIn]  |
| Sorg, Benjamin [VerfasserIn]  |
| Dürken, Matthias [VerfasserIn]  |
| Hecker-Nolting, Stefanie [VerfasserIn]  |
Titel: | Solitary pulmonary metastases at first recurrence of osteosarcoma |
Titelzusatz: | presentation, treatment, and survival of 219 patients of the Cooperative Osteosarcoma Study Group |
Verf.angabe: | Vanessa L. Mettmann, Daniel Baumhoer, Stefan S. Bielack, Claudia Blattmann, Godehard Friedel, Thekla von Kalle, Leo Kager, Matthias Kevric, Michaela Nathrath, Benjamin Sorg, Matthias Dürken, Stefanie Hecker-Nolting |
E-Jahr: | 2023 |
Jahr: | September 2023 |
Umfang: | 16 S. |
Illustrationen: | Illustrationen |
Fussnoten: | Online veröffentlicht: 7. August 2023 ; Gesehen am 01.08.2024 |
Titel Quelle: | Enthalten in: Cancer medicine |
Ort Quelle: | Hoboken, NJ : Wiley, 2012 |
Jahr Quelle: | 2023 |
Band/Heft Quelle: | 12(2023), 17 vom: Sept., Seite 18219-18234 |
ISSN Quelle: | 2045-7634 |
Abstract: | Background To evaluate patient and tumour characteristics, treatment and their impact on survival in patients with a solitary pulmonary metastasis at first relapse of high-grade osteosarcoma. Procedure Two-hundred and nineteen consecutive patients who had achieved a complete surgical remission and then developed a solitary pulmonary metastasis at first recurrence of high-grade osteosarcoma were retrospectively reviewed. Results Two hundred and three (94.9%) of 214 patients achieved a second complete remission. After a median time from initial diagnosis of osteosarcoma to first relapse of 2.3 years (range, 0.3-18.8 years), actuarial post-relapse overall survival after 2 and 5 years was 72.0% and 51.2%. Post-relapse event-free survival was 39.1% and 31.1%. Median follow-up time was 3.2 years (range, 0.1-29.4 years). A longer time until first relapse and diagnosis due to imaging were positive prognostic factors in uni- and multivariate analyses, as were a second complete surgical remission and, in regard to death, the absence of a subsequent relapse. The use of salvage chemotherapy and radiotherapy were not associated with patient outcomes, nor was the surgical approach (thoracoscopy vs. thoracotomy) nor the exploration (uni- vs. bilateral). Conclusion Approximately half of the patients who experience a solitary pulmonary relapse at first recurrence of osteosarcoma remain alive 5 years after this first relapse. Only one third will remain disease-free. A complete surgical resection of the lesion is essential for long-term survival while relapse chemotherapy does not seem to improve survival. Innovative therapies are required to improve outcomes. |
DOI: | doi:10.1002/cam4.6409 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1002/cam4.6409 |
| kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.6409 |
| DOI: https://doi.org/10.1002/cam4.6409 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | osteosarcoma |
| pulmonary metastases |
| recurrence |
| survival |
K10plus-PPN: | 1897355319 |
Verknüpfungen: | → Zeitschrift |
Solitary pulmonary metastases at first recurrence of osteosarcoma / Mettmann, Vanessa [VerfasserIn]; September 2023 (Online-Ressource)