Solitary pulmonary metastases at first recurrence of osteosarcoma

• Verfasst von: Mettmann, Vanessa [VerfasserIn]
• Verfasst von: Baumhoer, Daniel [VerfasserIn]
• Verfasst von: Bielack, Stefan S. [VerfasserIn]
• Verfasst von: Blattmann, Claudia [VerfasserIn]
• Verfasst von: Friedel, Godehard [VerfasserIn]
• Verfasst von: von Kalle, Thekla [VerfasserIn]
• Verfasst von: Kager, Leo [VerfasserIn]
• Verfasst von: Kevric, Matthias [VerfasserIn]
• Verfasst von: Nathrath, Michaela [VerfasserIn]
• Verfasst von: Sorg, Benjamin [VerfasserIn]
• Verfasst von: Dürken, Matthias [VerfasserIn]
• Verfasst von: Hecker-Nolting, Stefanie [VerfasserIn]
• Titel: Solitary pulmonary metastases at first recurrence of osteosarcoma
• Titelzusatz: presentation, treatment, and survival of 219 patients of the Cooperative Osteosarcoma Study Group
• Verf.angabe: Vanessa L. Mettmann, Daniel Baumhoer, Stefan S. Bielack, Claudia Blattmann, Godehard Friedel, Thekla von Kalle, Leo Kager, Matthias Kevric, Michaela Nathrath, Benjamin Sorg, Matthias Dürken, Stefanie Hecker-Nolting
• E-Jahr: 2023
• Jahr: September 2023
• Umfang: 16 S.
• Illustrationen: Illustrationen
• Fussnoten: Online veröffentlicht: 7. August 2023 ; Gesehen am 01.08.2024
• Titel Quelle: Enthalten in: Cancer medicine
• Ort Quelle: Hoboken, NJ : Wiley, 2012
• Jahr Quelle: 2023
• Band/Heft Quelle: 12(2023), 17 vom: Sept., Seite 18219-18234
• ISSN Quelle: 2045-7634
• DOI: doi:10.1002/cam4.6409
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: osteosarcoma
• Sach-SW: pulmonary metastases
• Sach-SW: recurrence
• Sach-SW: survival
• K10plus-PPN: 1897355319

Abstract

Background To evaluate patient and tumour characteristics, treatment and their impact on survival in patients with a solitary pulmonary metastasis at first relapse of high-grade osteosarcoma. Procedure Two-hundred and nineteen consecutive patients who had achieved a complete surgical remission and then developed a solitary pulmonary metastasis at first recurrence of high-grade osteosarcoma were retrospectively reviewed. Results Two hundred and three (94.9%) of 214 patients achieved a second complete remission. After a median time from initial diagnosis of osteosarcoma to first relapse of 2.3 years (range, 0.3-18.8 years), actuarial post-relapse overall survival after 2 and 5 years was 72.0% and 51.2%. Post-relapse event-free survival was 39.1% and 31.1%. Median follow-up time was 3.2 years (range, 0.1-29.4 years). A longer time until first relapse and diagnosis due to imaging were positive prognostic factors in uni- and multivariate analyses, as were a second complete surgical remission and, in regard to death, the absence of a subsequent relapse. The use of salvage chemotherapy and radiotherapy were not associated with patient outcomes, nor was the surgical approach (thoracoscopy vs. thoracotomy) nor the exploration (uni- vs. bilateral). Conclusion Approximately half of the patients who experience a solitary pulmonary relapse at first recurrence of osteosarcoma remain alive 5 years after this first relapse. Only one third will remain disease-free. A complete surgical resection of the lesion is essential for long-term survival while relapse chemotherapy does not seem to improve survival. Innovative therapies are required to improve outcomes.