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| Verfasst von: | Koumoundourou, Artemis [VerfasserIn]  |
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| | Rannap, Märt [VerfasserIn] |
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| | Bruyckere, Elodie de [VerfasserIn] |
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| | Nestel, Sigrun [VerfasserIn] |
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| | Reissner, Carsten [VerfasserIn] |
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| | Egorov, Alexei [VerfasserIn] |
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| | Liu, Pengtao [VerfasserIn] |
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| | Missler, Markus [VerfasserIn] |
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| | Heimrich, Bernd [VerfasserIn] |
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| | Draguhn, Andreas [VerfasserIn] |
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| | Britsch, Stefan [VerfasserIn] |
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| Titel: | Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway |
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| Verf.angabe: | Artemis Koumoundourou, Märt Rannap, Elodie De Bruyckere, Sigrun Nestel, Carsten Reissner, Alexei V Egorov, Pengtao Liu, Markus Missler, Bernd Heimrich, Andreas Draguhn, Stefan Britsch |
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| E-Jahr: | 2024 |
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| Jahr: | February 15, 2024 |
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| Umfang: | 31 S. |
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| Fussnoten: | Gesehen am 05.08.2024 |
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| Titel Quelle: | Enthalten in: eLife |
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| Ort Quelle: | Cambridge : eLife Sciences Publications, 2012 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 12(2024), Artikel-ID RP89854, Seite 1-31 |
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| ISSN Quelle: | 2050-084X |
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| Abstract: | The transcription factor Bcl11b has been linked to neurodevelopmental and neuropsychiatric disorders associated with synaptic dysfunction. Bcl11b is highly expressed in dentate gyrus granule neurons and is required for the structural and functional integrity of mossy fiber-CA3 synapses. The underlying molecular mechanisms, however, remained unclear. We show in mice that the synaptic organizer molecule C1ql2 is a direct functional target of Bcl11b that regulates synaptic vesicle recruitment and long-term potentiation at mossy fiber-CA3 synapses in vivo and in vitro. Furthermore, we demonstrate C1ql2 to exert its functions through direct interaction with a specific splice variant of neurexin-3, Nrxn3(25b+). Interruption of C1ql2-Nrxn3(25b+) interaction by expression of a non-binding C1ql2 mutant or by deletion of Nrxn3 in the dentate gyrus granule neurons recapitulates major parts of the Bcl11b as well as C1ql2 mutant phenotype. Together, this study identifies a novel C1ql2-Nrxn3(25b+)-dependent signaling pathway through which Bcl11b controls mossy fiber-CA3 synapse function. Thus, our findings contribute to the mechanistic understanding of neurodevelopmental disorders accompanied by synaptic dysfunction. |
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| DOI: | doi:10.7554/eLife.89854 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.7554/eLife.89854 |
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| | DOI: https://doi.org/10.7554/eLife.89854 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Bcl11b/Ctip2 |
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| | C1ql2 |
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| | mossy fiber-CA3 synapse |
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| | Neurexin |
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| | neurodevelopmental disorders |
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| | transcription factors |
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| K10plus-PPN: | 1897739869 |
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| Verknüpfungen: | → Zeitschrift |
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Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway / Koumoundourou, Artemis [VerfasserIn]; February 15, 2024 (Online-Ressource)
