Functional outcomes in conservatively vs surgically treated cerebellar infarcts

• Verfasst von: Won, Sae-Yeon [VerfasserIn]
• Verfasst von: Hernández-Durán, Silvia [VerfasserIn]
• Verfasst von: Behmanesh, Bedjan [VerfasserIn]
• Verfasst von: Bernstock, Joshua D. [VerfasserIn]
• Verfasst von: Czabanka, Marcus [VerfasserIn]
• Verfasst von: Dinc, Nazife [VerfasserIn]
• Verfasst von: Dubinski, Daniel [VerfasserIn]
• Verfasst von: Freiman, Thomas M. [VerfasserIn]
• Verfasst von: Günther, Albrecht [VerfasserIn]
• Verfasst von: Hellmuth, Kara [VerfasserIn]
• Verfasst von: Herrmann, Eva [VerfasserIn]
• Verfasst von: Konczalla, Juergen [VerfasserIn]
• Verfasst von: Maier, Ilko [VerfasserIn]
• Verfasst von: Melkonian, Ruzanna [VerfasserIn]
• Verfasst von: Mielke, Dorothee [VerfasserIn]
• Verfasst von: Naser, Paul [VerfasserIn]
• Verfasst von: Rohde, Veit [VerfasserIn]
• Verfasst von: Senft, Christian [VerfasserIn]
• Verfasst von: Storch, Alexander [VerfasserIn]
• Verfasst von: Unterberg, Andreas [VerfasserIn]
• Verfasst von: Walter, Johannes [VerfasserIn]
• Verfasst von: Walter, Uwe [VerfasserIn]
• Verfasst von: Wittstock, Matthias [VerfasserIn]
• Verfasst von: Schaefer, Jan Hendrik [VerfasserIn]
• Verfasst von: Geßler, Florian [VerfasserIn]
• Titel: Functional outcomes in conservatively vs surgically treated cerebellar infarcts
• Verf.angabe: Sae-YeonWon, MD; Silvia Hernández-Durán, MD; Bedjan Behmanesh, MD; Joshua D. Bernstock, MD, PhD, MPH; Marcus Czabanka, MD; Nazife Dinc, MD; Daniel Dubinski, MD, MSc; Thomas M. Freiman, MD; Albrecht Günther, MD; Kara Hellmuth, BSc; Eva Herrmann, PhD; Juergen Konczalla, MD; Ilko Maier, MD; Ruzanna Melkonian, MD; Dorothee Mielke, MD; Paul Naser, MD; Veit Rohde, MD; Christian Senft, MD; Alexander Storch, MD; Andreas Unterberg, MD; Johannes Walter, MD; Uwe Walter, MD; Matthias Wittstock, MD; Jan Hendrik Schaefer, MD; Florian Gessler, MD, PhD
• E-Jahr: 2024
• Jahr: February 26, 2024
• Umfang: 10 S.
• Fussnoten: Gesehen am 06.08.2024
• Titel Quelle: Enthalten in: JAMA neurology
• Ort Quelle: Chicago, Ill. : American Medical Association, 2013
• Jahr Quelle: 2024
• Band/Heft Quelle: 81(2024), 4, Seite 384-393
• ISSN Quelle: 2168-6157
• DOI: doi:10.1001/jamaneurol.2023.5773
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1897897413

Abstract

According to the current American Heart Association/American Stroke Association guidelines, decompressive surgery is indicated in patients with cerebellar infarcts that demonstrate severe cerebellar swelling. However, there is no universal definition of swelling and/or infarct volume(s) available to support a decision for surgery.To evaluate functional outcomes in surgically compared with conservatively managed patients with cerebellar infarcts.In this retrospective multicenter cohort study, patients with cerebellar infarcts treated at 5 tertiary referral hospitals or stroke centers within Germany between 2008 and 2021 were included. Data were analyzed from November 2020 to November 2023.Surgical treatment (ie, posterior fossa decompression plus standard of care) vs conservative management (ie, medical standard of care).The primary outcome examined was functional status evaluated by the modified Rankin Scale (mRS) at discharge and 1-year follow-up. Secondary outcomes included the predicted probabilities for favorable outcome (mRS score of 0 to 3) stratified by infarct volumes or Glasgow Coma Scale score at admission and treatment modality. Analyses included propensity score matching, with adjustments for age, sex, Glasgow Coma Scale score at admission, brainstem involvement, and infarct volume.Of 531 included patients with cerebellar infarcts, 301 (57%) were male, and the mean (SD) age was 68 (14.4) years. After propensity score matching, a total of 71 patients received surgical treatment and 71 patients conservative treatment. There was no significant difference in favorable outcomes (ie, mRS score of 0 to 3) at discharge for those treated surgically vs conservatively (47 [66%] vs 45 [65%]; odds ratio, 1.1; 95% CI, 0.5-2.2; P > .99) or at follow-up (35 [73%] vs 33 [61%]; odds ratio, 1.8; 95% CI, 0.7-4.2; P > .99). In patients with cerebellar infarct volumes of 35 mL or greater, surgical treatment was associated with a significant improvement in favorable outcomes at 1-year follow-up (38 [61%] vs 3 [25%]; odds ratio, 4.8; 95% CI, 1.2-19.3; P = .03), while conservative treatment was associated with favorable outcomes at 1-year follow-up in patients with infarct volumes of less than 25 mL (2 [34%] vs 218 [74%]; odds ratio, 0.2; 95% CI, 0-1.0; P = .047).Overall, surgery was not associated with improved outcomes compared with conservative management in patients with cerebellar infarcts. However, when stratifying based on infarct volume, surgical treatment appeared to be beneficial in patients with larger infarct volumes, while conservative management appeared favorable in patients with smaller infarct volumes.