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| Verfasst von: | Galbraith, Kristyn [VerfasserIn]  |
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| | Garcia, Mekka [VerfasserIn] |
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| | Wei, Siyu [VerfasserIn] |
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| | Chen, Anna [VerfasserIn] |
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| | Schroff, Chanel [VerfasserIn] |
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| | Serrano, Jonathan [VerfasserIn] |
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| | Pacione, Donato [VerfasserIn] |
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| | Placantonakis, Dimitris G [VerfasserIn] |
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| | William, Christopher M [VerfasserIn] |
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| | Faustin, Arline [VerfasserIn] |
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| | Zagzag, David [VerfasserIn] |
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| | Barbaro, Marissa [VerfasserIn] |
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| | Eibl, Maria Del Pilar Guillermo Prieto [VerfasserIn] |
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| | Shirahata, Mitsuaki [VerfasserIn] |
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| | Reuss, David [VerfasserIn] |
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| | Tran, Quynh T [VerfasserIn] |
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| | Alom, Zahangir [VerfasserIn] |
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| | Deimling, Andreas von [VerfasserIn] |
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| | Orr, Brent A [VerfasserIn] |
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| | Sulman, Erik P [VerfasserIn] |
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| | Golfinos, John G [VerfasserIn] |
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| | Orringer, Daniel A [VerfasserIn] |
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| | Jain, Rajan [VerfasserIn] |
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| | Lieberman, Evan [VerfasserIn] |
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| | Feng, Yang [VerfasserIn] |
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| | Snuderl, Matija [VerfasserIn] |
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| Titel: | Prognostic value of DNA methylation subclassification, aneuploidy, and CDKN2A/B homozygous deletion in predicting clinical outcome of IDH mutant astrocytomas |
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| Verf.angabe: | Kristyn Galbraith, Mekka Garcia, Siyu Wei, Anna Chen, Chanel Schroff, Jonathan Serrano, Donato Pacione, Dimitris G. Placantonakis, Christopher M. William, Arline Faustin, David Zagzag, Marissa Barbaro, Maria Del Pilar Guillermo Prieto Eibl, Mitsuaki Shirahata, David Reuss, Quynh T. Tran, Zahangir Alom, Andreas von Deimling, Brent A. Orr, Erik P. Sulman, John G. Golfinos, Daniel A. Orringer, Rajan Jain, Evan Lieberman, Yang Feng, and Matija Snuderl |
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| E-Jahr: | 2024 |
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| Jahr: | June 2024 |
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| Umfang: | 10 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online veröffentlicht: 19. Januar 2024 ; Gesehen am 06.08.2024 |
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| Titel Quelle: | Enthalten in: Neuro-Oncology |
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| Ort Quelle: | Oxford : Oxford Univ. Press, 1999 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 26(2024), 6 vom: Juni, Seite 1042-1051 |
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| ISSN Quelle: | 1523-5866 |
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| Abstract: | Isocitrate dehydrogenase (IDH) mutant astrocytoma grading, until recently, has been entirely based on morphology. The 5th edition of the Central Nervous System World Health Organization (WHO) introduces CDKN2A/B homozygous deletion as a biomarker of grade 4. We sought to investigate the prognostic impact of DNA methylation-derived molecular biomarkers for IDH mutant astrocytoma.We analyzed 98 IDH mutant astrocytomas diagnosed at NYU Langone Health between 2014 and 2022. We reviewed DNA methylation subclass, CDKN2A/B homozygous deletion, and ploidy and correlated molecular biomarkers with histological grade, progression free (PFS), and overall (OS) survival. Findings were confirmed using 2 independent validation cohorts.There was no significant difference in OS or PFS when stratified by histologic WHO grade alone, copy number complexity, or extent of resection. OS was significantly different when patients were stratified either by CDKN2A/B homozygous deletion or by DNA methylation subclass (P value = .0286 and .0016, respectively). None of the molecular biomarkers were associated with significantly better PFS, although DNA methylation classification showed a trend (P value = .0534).The current WHO recognized grading criteria for IDH mutant astrocytomas show limited prognostic value. Stratification based on DNA methylation shows superior prognostic value for OS. |
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| DOI: | doi:10.1093/neuonc/noae009 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1093/neuonc/noae009 |
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| | Volltext: https://academic.oup.com/neuro-oncology/article/26/6/1042/7578744 |
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| | DOI: https://doi.org/10.1093/neuonc/noae009 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1897900163 |
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| Verknüpfungen: | → Zeitschrift |
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Prognostic value of DNA methylation subclassification, aneuploidy, and CDKN2A/B homozygous deletion in predicting clinical outcome of IDH mutant astrocytomas / Galbraith, Kristyn [VerfasserIn]; June 2024 (Online-Ressource)
