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| Verfasst von: | Humblin, Etienne [VerfasserIn]  |
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| | Korpas, Isabel [VerfasserIn] |
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| | Lu, Jiahua [VerfasserIn] |
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| | Filipescu, Dan [VerfasserIn] |
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| | van der Heide, Verena [VerfasserIn] |
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| | Goldstein, Simon [VerfasserIn] |
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| | Vaidya, Abishek [VerfasserIn] |
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| | Soares-Schanoski, Alessandra [VerfasserIn] |
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| | Casati, Beatrice [VerfasserIn] |
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| | Selvan, Myvizhi E. [VerfasserIn] |
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| | Gümüş, Zeynep H. [VerfasserIn] |
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| | Wieland, Andreas [VerfasserIn] |
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| | Corrado, Mauro [VerfasserIn] |
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| | Cohen-Gould, Leona [VerfasserIn] |
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| | Bernstein, Emily [VerfasserIn] |
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| | Homann, Dirk [VerfasserIn] |
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| | Chipuk, Jerry [VerfasserIn] |
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| | Kamphorst, Alice O. [VerfasserIn] |
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| Titel: | Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1+ PD-1+ CD8 T cells |
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| Verf.angabe: | Etienne Humblin, Isabel Korpas, Jiahua Lu, Dan Filipescu, Verena van der Heide, Simon Goldstein, Abishek Vaidya, Alessandra Soares-Schanoski, Beatrice Casati, Myvizhi E. Selvan, Zeynep H. Gümüş, Andreas Wieland, Mauro Corrado, Leona Cohen-Gould, Emily Bernstein, Dirk Homann, Jerry Chipuk, Alice O. Kamphorst |
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| E-Jahr: | 2023 |
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| Jahr: | August 25, 2023 |
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| Umfang: | 13 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Im Titel ist "+" jeweils hochgestellt ; Gesehen am 06.08.2024 |
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| Titel Quelle: | Enthalten in: Science immunology |
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| Ort Quelle: | Washington, DC : AAAS, 2016 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 8(2023), 86 vom: Aug., Artikel-ID eadg0878, Seite 1-13 |
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| ISSN Quelle: | 2470-9468 |
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| Abstract: | During persistent antigen stimulation, such as in chronic infections and cancer, CD8 T cells differentiate into a hypofunctional programmed death protein 1-positive (PD-1+) exhausted state. Exhausted CD8 T cell responses are maintained by precursors (Tpex) that express the transcription factor T cell factor 1 (TCF-1) and high levels of the costimulatory molecule CD28. Here, we demonstrate that sustained CD28 costimulation is required for maintenance of antiviral T cells during chronic infection. Low-level CD28 engagement preserved mitochondrial fitness and self-renewal of Tpex, whereas stronger CD28 signaling enhanced glycolysis and promoted Tpex differentiation into TCF-1neg exhausted CD8 T cells (Tex). Furthermore, enhanced differentiation by CD28 engagement did not reduce the Tpex pool. Together, these findings demonstrate that continuous CD28 engagement is needed to sustain PD-1+ CD8 T cells and suggest that increasing CD28 signaling promotes Tpex differentiation into more functional effector-like Tex, possibly without compromising long-term responses. |
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| DOI: | doi:10.1126/sciimmunol.adg0878 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1126/sciimmunol.adg0878 |
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| | DOI: https://doi.org/10.1126/sciimmunol.adg0878 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CD28 Antigens |
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| | CD8-Positive T-Lymphocytes |
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| | Cell Differentiation |
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| | Programmed Cell Death 1 Receptor |
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| | T Cell Transcription Factor 1 |
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| | Transcription Factors |
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| K10plus-PPN: | 1897923457 |
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| Verknüpfungen: | → Zeitschrift |
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Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1+ PD-1+ CD8 T cells / Humblin, Etienne [VerfasserIn]; August 25, 2023 (Online-Ressource)
