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Status: Bibliographieeintrag

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Verfasst von:Zylla, Maura Magdalena [VerfasserIn]   i
 Wolfes, Julian [VerfasserIn]   i
 Schleberger, Ruben [VerfasserIn]   i
 Lawin, Dennis [VerfasserIn]   i
 Kieser, Meinhard [VerfasserIn]   i
 Reinke, Florian [VerfasserIn]   i
 Eckardt, Lars [VerfasserIn]   i
 Rillig, Andreas [VerfasserIn]   i
 Stellbrink, Christoph [VerfasserIn]   i
 Thomas, Dierk [VerfasserIn]   i
 Frey, Norbert [VerfasserIn]   i
 Lugenbiel, Patrick [VerfasserIn]   i
Titel:Use of class IC antiarrhythmic drugs in patients with structural heart disease and implantable cardioverter defibrillator
Verf.angabe:Maura M. Zylla, Julian Wolfes, Ruben Schleberger, Dennis Lawin, Meinhard Kieser, Florian Reinke, Lars Eckardt, Andreas Rillig, Christoph Stellbrink, Dierk Thomas, Norbert Frey, Patrick Lugenbiel
E-Jahr:2024
Jahr:19 February 2024
Umfang:9 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 06.08.2024
Titel Quelle:Enthalten in: Clinical research in cardiology
Ort Quelle:Berlin : Springer, 2006
Jahr Quelle:2024
Band/Heft Quelle:113(2024), 6, Seite 933-941
ISSN Quelle:1861-0692
Abstract:BACKGROUND: Due to suspected pro-arrhythmic effects and increased mortality associated with class-IC antiarrhythmic drugs (AADs) in previous trials, AAD therapy in structural heart disease (SHD) is mainly restricted to amiodarone. In the presence of diagnostic and therapeutic advancements in cardiovascular medicine, it remains unclear if previous studies adequately reflect contemporary patients. In clinical practice, class-IC-AADs are occasionally used in individual cases, particularly in patients with an implantable cardioverter defibrillator (ICD). - METHODS: This study retrospectively investigated outcome in ICD-carriers with SHD in whom class-IC-AADs were used as an individualized therapy due to failure, side effects, or unacceptable risk of alternative therapeutic options. - RESULTS: Fifty patients from four tertiary centers were included (median age 48.5 years; 52% female). The most common underlying SHD were dilated (42%) or ischemic cardiomyopathy (26%) (median LVEF = 45%). Indications for AAD were sustained ventricular arrhythmias (VA) (58%), symptomatic premature ventricular contractions (26%), or atrial arrhythmias (16%). Median follow-up was 27.8 months. Freedom from sustained VA was 72%, and freedom from ICD therapy was 80%. In 19 patients (38%), AAD therapy was terminated. The most common reason was insufficient efficacy (n = 8). Pro-arrhythmia was suspected in three patients. Five patients died during follow-up (10.0%), two of cardiovascular cause (4.0%). - CONCLUSION: In a multicenter cohort of ICD-carriers with SHD, class-IC-AADs were associated with a low rate of pro-arrhythmic effects or cardiovascular mortality. The majority of patients remained free from sustained VA during a follow-up of > 2 years. Further efforts should be made to evaluate the safety of class-IC-AADs in SHD patients receiving contemporary cardiovascular therapy.
DOI:doi:10.1007/s00392-024-02394-6
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1007/s00392-024-02394-6
 DOI: https://doi.org/10.1007/s00392-024-02394-6
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adult
 Aged
 Anti-Arrhythmia Agents
 Arrhythmias, Cardiac
 Class-IC antiarrhythmic drugs
 Defibrillators, Implantable
 Female
 Follow-Up Studies
 Humans
 Implantable cardioverter defibrillator
 Male
 Middle Aged
 Retrospective Studies
 Structural heart disease
 Sudden cardiac death
 Treatment Outcome
 Ventricular arrhythmia
K10plus-PPN:1897927681
Verknüpfungen:→ Zeitschrift

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