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Verfasst von:Llamosas-Falcón, Laura [VerfasserIn]   i
 Rehm, Jürgen [VerfasserIn]   i
 Bright, Sophie [VerfasserIn]   i
 Buckley, Charlotte [VerfasserIn]   i
 Carr, Tessa [VerfasserIn]   i
 Kilian, Carolin [VerfasserIn]   i
 Lasserre, Aurélie M. [VerfasserIn]   i
 Lemp, Julia M. [VerfasserIn]   i
 Zhu, Yachen [VerfasserIn]   i
 Probst, Charlotte [VerfasserIn]   i
Titel:The relationship between alcohol consumption, BMI, and type 2 diabetes
Titelzusatz:a systematic review and dose-response meta-analysis
Verf.angabe:Laura Llamosas-Falcón, Jürgen Rehm, Sophie Bright, Charlotte Buckley, Tessa Carr, Carolin Kilian, Aurélie M. Lasserre, Julia M. Lemp, Yachen Zhu, and Charlotte Probst
E-Jahr:2023
Jahr:November 2023
Umfang:8 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 06.08.2024
Titel Quelle:Enthalten in: Diabetes care
Ort Quelle:Alexandria, Va. : Assoc., 1978
Jahr Quelle:2023
Band/Heft Quelle:46(2023), 11, Seite 2076-2083
ISSN Quelle:1935-5548
Abstract:Moderate alcohol use may be associated with lower risk of type 2 diabetes mellitus (T2DM). Previous reviews have reached mixed conclusions.To quantify the dose-response relationship between alcohol consumption and T2DM, accounting for differential effects by sex and BMI.Medline, Embase, Web of Science, and one secondary data source.Cohort studies on the relationship between alcohol use and T2DM.Fifty-five studies, and one secondary data source, were included with a combined sample size of 1,363,355 men and 1,290,628 women, with 89,983 and 57,974 individuals, respectively, diagnosed with T2DM.Multivariate dose-response meta-analytic random-effect models were used. For women, a J-shaped relationship was found with a maximum risk reduction of 31% (relative risk [RR] 0.69, 95% CI 0.64-0.74) at an intake of 16 g of pure alcohol per day compared with lifetime abstainers. The protective association ceased above 49 g per day (RR 0.82, 95% CI 0.68-0.99). For men, no statistically significant relationship was identified. When results were stratified by BMI, the protective association was only found in overweight and obese women.Our analysis relied on aggregate data. We included some articles that determined exposure and cases via self-report, and the studies did not account for temporal variations in alcohol use.The observed reduced risk seems to be specific to women in general and women with a BMI ≥25 kg/m2. Our findings allow for a more precise prediction of the sex-specific relationship between T2DM and alcohol use, as our results differ from those of previous studies.
DOI:doi:10.2337/dc23-1015
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.2337/dc23-1015
 Volltext: https://diabetesjournals.org/care/article/46/11/2076/153773
 DOI: https://doi.org/10.2337/dc23-1015
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1897945345
Verknüpfungen:→ Zeitschrift

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