Ab initio tertiary-fold prediction of helical and non-helical protein chains using a genetic algorithm

• Verfasst von: Dandekar, Thomas [VerfasserIn]
• Verfasst von: Argos, Patrick [VerfasserIn]
• Titel: Ab initio tertiary-fold prediction of helical and non-helical protein chains using a genetic algorithm
• Verf.angabe: T. Dandekar, P. Argos
• E-Jahr: 1996
• Jahr: February 1996
• Umfang: 4 S.
• Fussnoten: Elektronische Reproduktion der Druck-Ausgabe 1. Dezember 1999 ; Gesehen am 08.08.2024
• Titel Quelle: Enthalten in: International journal of biological macromolecules
• Ort Quelle: New York, NY [u.a.] : Elsevier, 1979
• Jahr Quelle: 1996
• Band/Heft Quelle: 18(1996), 1, Seite 1-4
• ISSN Quelle: 1879-0003
• DOI: doi:10.1016/0141-8130(95)01036-X
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Main-chain topology
• Sach-SW: Protein structure prediction
• Sach-SW: Simulated evolution
• K10plus-PPN: 1898170002

Abstract

In this study, protein structures were predicted using a genetic algorithm. Optimal structures were selected according to basic protein-building principles. Having previously applied this approach to proteins with helical topology, this paper reports preliminary results on 3 proteins with mixed topology (helical and non-helical, e.g. sheet). The method seems to be generally applicable to protein-fold prediction since topology predictions close to the observed experimental structures are obtained.