| |  Online-Ressource |
|---|
| Verfasst von: | März, Winfried [VerfasserIn]  |
|---|
| | Schmidt, Nina [VerfasserIn] |
|---|
| | an Haack, Ira [VerfasserIn] |
|---|
| | Dressel, Alexander [VerfasserIn] |
|---|
| | Grammer, Tanja B. [VerfasserIn] |
|---|
| | Kleber, Marcus E. [VerfasserIn] |
|---|
| | Baessler, Andrea [VerfasserIn] |
|---|
| | Beil, F. Ulrich [VerfasserIn] |
|---|
| | Gouni-Berthold, Ioanna [VerfasserIn] |
|---|
| | Julius, Ulrich [VerfasserIn] |
|---|
| | Kassner, Ursula [VerfasserIn] |
|---|
| | Katzmann, Julius L. [VerfasserIn] |
|---|
| | Klose, Gerald [VerfasserIn] |
|---|
| | König, Christel [VerfasserIn] |
|---|
| | Koenig, Wolfgang [VerfasserIn] |
|---|
| | Koschker, Ann-Cathrin [VerfasserIn] |
|---|
| | Laufs, Ulrich [VerfasserIn] |
|---|
| | Merkel, Martin [VerfasserIn] |
|---|
| | Otte, Britta [VerfasserIn] |
|---|
| | Parhofer, Klaus G. [VerfasserIn] |
|---|
| | Hengstenberg, Wibke [VerfasserIn] |
|---|
| | Schunkert, Heribert [VerfasserIn] |
|---|
| | Stach-Jablonski, Ksenija [VerfasserIn] |
|---|
| | Steinhagen-Thiessen, Elisabeth [VerfasserIn] |
|---|
| | Olivier, Christoph [VerfasserIn] |
|---|
| | Hahmann, Harry [VerfasserIn] |
|---|
| | Krzossok, Stefan [VerfasserIn] |
|---|
| | Vogt, Anja [VerfasserIn] |
|---|
| | Müller-Wieland, Dirk [VerfasserIn] |
|---|
| | Schatz, Ulrike [VerfasserIn] |
|---|
| Titel: | The German CaRe high registry for familial hypercholesterolemia |
|---|
| Titelzusatz: | Sex differences, treatment strategies, and target value attainment |
|---|
| Verf.angabe: | Winfried März, Nina Schmidt, Ira an Haack, Alexander Dressel, Tanja B. Grammer, Marcus E. Kleber, Andrea Baessler, F. Ulrich Beil, Ioanna Gouni-Berthold, Ulrich Julius, Ursula Kassner, Julius L. Katzmann, Gerald Klose, Christel König, Wolfgang Koenig, Ann-Cathrin Koschker, Ulrich Laufs, Martin Merkel, Britta Otte, Klaus G. Parhofer, Wibke Hengstenberg, Heribert Schunkert, Ksenija Stach-Jablonski, Elisabeth Steinhagen-Thiessen, Christoph B. Olivier, Harry Hahmann, Stefan Krzossok, Anja Vogt, Dirk Müller-Wieland, Ulrike Schatz |
|---|
| E-Jahr: | 2023 |
|---|
| Jahr: | September 2023 |
|---|
| Umfang: | 10 S. |
|---|
| Illustrationen: | Illustrationen |
|---|
| Fussnoten: | Online verfügbar: 12. Juni 2023, Artikelversion: 21. Juni 2023 ; Gesehen am 08.08.2024 |
|---|
| Titel Quelle: | Enthalten in: Atherosclerosis plus |
|---|
| Ort Quelle: | Amsterdam] : Elsevier B.V., 2021 |
|---|
| Jahr Quelle: | 2023 |
|---|
| Band/Heft Quelle: | 53(2023), Seite 6-15 |
|---|
| ISSN Quelle: | 2667-0895 |
|---|
| Abstract: | Background and aims - Familial hypercholesterolemia (FH) is among the most common genetic disorders in primary care. However, only 15% or less of patients are diagnosed, and few achieve the goals for low-density lipoprotein cholesterol (LDL-C). In this analysis of the German Cascade Screening and Registry for High Cholesterol (CaRe High), we examined the status of lipid management, treatment strategies, and LDL-C goal attainment according to the ESC/EAS dyslipidemia guidelines. - Methods - We evaluated consolidated datasets from 1501 FH patients diagnosed clinically and seen either by lipid specialists or general practitioners and internists. We conducted a questionnaire survey of both the recruiting physicians and patients. - Results - Among the 1501 patients, 86% regularly received lipid-lowering drugs. LDL-C goals were achieved by 26% and 10% of patients with atherosclerotic cardiovascular disease (ASCVD) according to the 2016 and 2019 ESC/EAS dyslipidemia guidelines, respectively. High intensity lipid-lowering was administered more often in men than in women, in patients with ASCVD, at higher LDL-C and in patients with a genetic diagnosis of FH. - Conclusions - FH is under-treated in Germany compared to guideline recommendations. Male gender, genetic proof of FH, treatment by a specialist, and presence of ASCVD appear to be associated with increased treatment intensity. Achieving the LDL-C goals of the 2019 ESC/EAS dyslipidemia guidelines remains challenging if pre-treatment LDL-C is very high. |
|---|
| DOI: | doi:10.1016/j.athplu.2023.06.001 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.athplu.2023.06.001 |
|---|
| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S2667089523000093 |
|---|
| | DOI: https://doi.org/10.1016/j.athplu.2023.06.001 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Adherence |
|---|
| | Cardiovascular risk |
|---|
| | Cascade screening |
|---|
| | Familial hypercholesterolemia |
|---|
| | Low-density lipoproteins |
|---|
| | Patient registry |
|---|
| | Treatment |
|---|
| K10plus-PPN: | 1898178011 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
¬The¬ German CaRe high registry for familial hypercholesterolemia / März, Winfried [VerfasserIn]; September 2023 (Online-Ressource)
