Smoking influence in Takotsubo syndrome

• Verfasst von: Núñez-Gil, Iván J. [VerfasserIn]
• Verfasst von: Santoro, Francesco [VerfasserIn]
• Verfasst von: Vazirani, Ravi [VerfasserIn]
• Verfasst von: Novo, Giuseppina [VerfasserIn]
• Verfasst von: Blanco-Ponce, Emilia [VerfasserIn]
• Verfasst von: Arcari, Luca [VerfasserIn]
• Verfasst von: Uribarri, Aitor [VerfasserIn]
• Verfasst von: Cacciotti, Luca [VerfasserIn]
• Verfasst von: Guerra, Federico [VerfasserIn]
• Verfasst von: Salamanca, Jorge [VerfasserIn]
• Verfasst von: Musumeci, Beatrice [VerfasserIn]
• Verfasst von: Vedia, Oscar [VerfasserIn]
• Verfasst von: Mariano, Enrica [VerfasserIn]
• Verfasst von: Fernández-Cordón, Clara [VerfasserIn]
• Verfasst von: Caldarola, Pasquale [VerfasserIn]
• Verfasst von: Montisci, Roberta [VerfasserIn]
• Verfasst von: Brunetti, Natale Daniele [VerfasserIn]
• Verfasst von: El-Battrawy, Ibrahim [VerfasserIn]
• Verfasst von: Abumayyaleh, Mohammad S. A. [VerfasserIn]
• Verfasst von: Akın, Ibrahim [VerfasserIn]
• Verfasst von: Eitel, Ingo [VerfasserIn]
• Verfasst von: Stiermaier, Thomas [VerfasserIn]
• Titel: Smoking influence in Takotsubo syndrome
• Titelzusatz: insights from an international cohort
• Verf.angabe: Iván J. Núñez-Gil, Francesco Santoro, Ravi Vazirani, Giuseppina Novo, Emilia Blanco-Ponce, Luca Arcari, Aitor Uribarri, Luca Cacciotti, Federico Guerra, Jorge Salamanca, Beatrice Musumeci, Oscar Vedia, Enrica Mariano, Clara Fernández-Cordón, Pasquale Caldarola, Roberta Montisci, Natale Daniele Brunetti, Ibrahim El-Battrawy, Mohammad Abumayyaleh, Ibrahim Akin, Ingo Eitel and Thomas Stiermaier
• E-Jahr: 2023
• Jahr: 20 November 2023
• Umfang: 9 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 13.08.2024
• Titel Quelle: Enthalten in: Frontiers in Cardiovascular Medicine
• Ort Quelle: Lausanne : Frontiers Media, 2014
• Jahr Quelle: 2023
• Band/Heft Quelle: 10(2023), Seite 1-9
• ISSN Quelle: 2297-055X
• DOI: doi:10.3389/fcvm.2023.1282018
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Apical ballooning
• Sach-SW: Mortality
• Sach-SW: prognosis
• Sach-SW: Registry
• Sach-SW: Smoking habit
• Sach-SW: Takotsubo syndrome
• K10plus-PPN: 1898503427

Abstract

Aims: To assess the influence of tobacco on acute and long-term outcomes in Takotsubo syndrome (TTS). Methods: Patients with TTS from the international multicenter German Italian Spanish Takotsubo registry (GEIST) were analyzed. Comparisons between groups were performed within the overall cohort, and an adjusted analysis with 1:1 propensity score matching was conducted. Results: Out of 3,152 patients with TTS, 534 (17%) were current smokers. Smoker TTS patients were younger (63 ± 11 vs. 72 ± 11 years, p 0.001), less frequently women (78% vs. 90%, p 0.001), and had a lower prevalence of hypertension (59% vs. 69%, p 0.01) and diabetes mellitus (16% vs. 20%, p = 0.04), but had a higher prevalence of pulmonary (21% vs. 15%, p 0.01) and/or psychiatric diseases (17% vs. 12%, p 0.01). On multivariable analysis, age less than 65 years [OR 3.85, 95% CI (2.86-5)], male gender [OR 2.52, 95% CI (1.75-3.64)], history of pulmonary disease [OR 2.56, 95% CI (1.81-3.61)], coronary artery disease [OR 2.35, 95% CI (1.60-3.46)], and non-apical ballooning form [OR 1.47, 95% CI (1.02-2.13)] were associated with smoking status. Propensity score matching (PSM) 1:1 yielded 329 patients from each group. Smokers had a similar rate of in-hospital complications but longer in-hospital stays (10 vs. 9 days, p = 0.01). During long-term follow-up, there were no differences in mortality rates between smokers and non-smokers (5.6% vs. 6.9% yearly in the overall, p = 0.02, and 6.6%, vs. 7.2% yearly in the matched cohort, p = 0.97). Conclusions: Our findings suggest that smoking may influence the clinical presentation and course of TTS with longer in-hospital stays, but does not independently impact mortality.